Peptidyl-prolyl cis-trans isomerase…

About Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (PIN4) is a protein from Homo sapiens identified by UniProt accession Q9Y237, 131 residues long. MolForge cross-references it against 0 known binders and 22 disease associations.

Target properties

Protein name	Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4
UniProt accession	Q9Y237
Gene	PIN4
Organism	Homo sapiens
Length	131 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (22)

Diseases linked to this target (Open Targets).

systolic blood pressure · score 0.25
uric acid measurement · score 0.17
hepatocellular carcinoma · score 0.06
hepatitis B virus infection · score 0.02
neoplasm · score 0.02
cyst · score 0.01
chronic hepatitis B virus infection · score 0.01
allergic rhinitis · score 0.01
cancer · score 0.01
infection · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y237-F1	alphafold	PREDICTED	78.60	—

Amino-acid sequence (131 residues)

MPPKGKSGSG KAGKGGAASG SDSADKKAQG PKGGGNAVKV RHILCEKHGK IMEAMEKLKS GMRFNEVAAQ YSEDKARQGG DLGWMTRGSM VGPFQEAAFA LPVSGMDKPV FTDPPVKTKF GYHIIMVEGR K

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Peptidyl-prolyl cis-trans isomerase NIMA-interacting 4 (PIN4)