About RAC-gamma serine/threonine-protein kinase
RAC-gamma serine/threonine-protein kinase (AKT3) is a protein
from Homo sapiens identified by UniProt accession
Q9Y243, 479 residues long.
MolForge cross-references it against 0 known binders and
534 disease associations.
Target properties
| Protein name | RAC-gamma serine/threonine-protein kinase |
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| UniProt accession | Q9Y243 |
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| Gene | AKT3 |
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| Organism | Homo sapiens |
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| Length | 479 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (2)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (534)
Diseases linked to this target (Open Targets).
- megalencephaly-polymicrogyria-polydactyly-hydrocephalus syndrome 2 · score 0.80
- Megalencephaly - polymicrogyria - postaxial polydactyly - hydrocephalus · score 0.67
- overgrowth syndrome and/or cerebral malformations due to abnormalities in MTOR pathway genes · score 0.46
- cancer · score 0.45
- schizophrenia · score 0.43
- body mass index · score 0.43
- glioma · score 0.42
- breast cancer · score 0.41
- body height · score 0.39
- monocyte count · score 0.39
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y243-F1 | alphafold | PREDICTED | 82.07 | — |
Amino-acid sequence (479 residues)
MSDVTIVKEG WVQKRGEYIK NWRPRYFLLK TDGSFIGYKE KPQDVDLPYP LNNFSVAKCQ LMKTERPKPN TFIIRCLQWT TVIERTFHVD TPEEREEWTE AIQAVADRLQ RQEEERMNCS PTSQIDNIGE EEMDASTTHH KRKTMNDFDY LKLLGKGTFG KVILVREKAS GKYYAMKILK KEVIIAKDEV AHTLTESRVL KNTRHPFLTS LKYSFQTKDR LCFVMEYVNG GELFFHLSRE RVFSEDRTRF YGAEIVSALD YLHSGKIVYR DLKLENLMLD KDGHIKITDF GLCKEGITDA ATMKTFCGTP EYLAPEVLED NDYGRAVDWW GLGVVMYEMM CGRLPFYNQD HEKLFELILM EDIKFPRTLS SDAKSLLSGL LIKDPNKRLG GGPDDAKEIM RHSFFSGVNW QDVYDKKLVP PFKPQVTSET DTRYFDEEFT AQTITITPPE KYDEDGMDCM DNERRPHFPQ FSYSASGRE
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