About Proteasome maturation protein
Proteasome maturation protein (POMP) is a protein
from Homo sapiens identified by UniProt accession
Q9Y244, 141 residues long.
MolForge cross-references it against 0 known binders and
33 disease associations.
Target properties
| Protein name | Proteasome maturation protein |
|---|
| UniProt accession | Q9Y244 |
|---|
| Gene | POMP |
|---|
| Organism | Homo sapiens |
|---|
| Length | 141 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (33)
Diseases linked to this target (Open Targets).
- proteasome-associated autoinflammatory syndrome 2 · score 0.62
- keratosis linearis-ichthyosis congenita-sclerosing keratoderma syndrome · score 0.59
- hemoglobin measurement · score 0.36
- hematocrit · score 0.36
- erythrocyte count · score 0.35
- red blood cell density measurement · score 0.32
- mean corpuscular hemoglobin concentration · score 0.25
- genetic disorder · score 0.18
- adolescent idiopathic scoliosis · score 0.11
- triglyceride measurement · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y244-F1 | alphafold | PREDICTED | 80.99 | — |
Amino-acid sequence (141 residues)
MNARGLGSEL KDSIPVTELS ASGPFESHDL LRKGFSCVKN ELLPSHPLEL SEKNFQLNQD KMNFSTLRNI QGLFAPLKLQ MEFKAVQQVQ RLPFLSSSNL SLDVLRGNDE TIGFEDILND PSQSEVMGEP HLMVEYKLGL L
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