About DNA replication complex GINS protein PSF2
DNA replication complex GINS protein PSF2 (GINS2) is a protein
from Homo sapiens identified by UniProt accession
Q9Y248, 185 residues long.
MolForge cross-references it against 0 known binders and
132 disease associations.
Target properties
| Protein name | DNA replication complex GINS protein PSF2 |
|---|
| UniProt accession | Q9Y248 |
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| Gene | GINS2 |
|---|
| Organism | Homo sapiens |
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| Length | 185 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (132)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.35
- type 2 diabetes mellitus · score 0.34
- alcohol consumption measurement · score 0.34
- serum gamma-glutamyl transferase measurement · score 0.30
- platelet count · score 0.29
- alcohol use disorder measurement · score 0.26
- mean platelet volume · score 0.25
- triglyceride measurement · score 0.21
- brain measurement · score 0.19
- platelet component distribution width · score 0.19
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y248-F1 | alphafold | PREDICTED | 93.14 | — |
Amino-acid sequence (185 residues)
MDAAEVEFLA EKELVTIIPN FSLDKIYLIG GDLGPFNPGL PVEVPLWLAI NLKQRQKCRL LPPEWMDVEK LEKMRDHERK EETFTPMPSP YYMELTKLLL NHASDNIPKA DEIRTLVKDM WDTRIAKLRV SADSFVRQQE AHAKLDNLTL MEINTSGTFL TQALNHMYKL RTNLQPLEST QSQDF
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