About Leucine zipper putative tumor suppressor 1
Leucine zipper putative tumor suppressor 1 (LZTS1) is a protein
from Homo sapiens identified by UniProt accession
Q9Y250, 596 residues long.
MolForge cross-references it against 0 known binders and
126 disease associations.
Target properties
| Protein name | Leucine zipper putative tumor suppressor 1 |
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| UniProt accession | Q9Y250 |
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| Gene | LZTS1 |
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| Organism | Homo sapiens |
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| Length | 596 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (126)
Diseases linked to this target (Open Targets).
- esophageal squamous cell carcinoma · score 0.51
- neurodegenerative disease · score 0.43
- esophageal cancer · score 0.37
- urate measurement · score 0.27
- bone density · score 0.27
- body mass index · score 0.22
- PHF-tau measurement · score 0.22
- beta-amyloid 1-42 measurement · score 0.16
- body height · score 0.15
- hepatitis B virus infection · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y250-F1 | alphafold | PREDICTED | 68.14 | — |
Amino-acid sequence (596 residues)
MGSVSSLISG HSFHSKHCRA SQYKLRKSSH LKKLNRYSDG LLRFGFSQDS GHGKSSSKMG KSEDFFYIKV SQKARGSHHP DYTALSSGDL GGQAGVDFDP STPPKLMPFS NQLEMGSEKG AVRPTAFKPV LPRSGAILHS SPESASHQLH PAPPDKPKEQ ELKPGLCSGA LSDSGRNSMS SLPTHSTSSS YQLDPLVTPV GPTSRFGGSA HNITQGIVLQ DSNMMSLKAL SFSDGGSKLG HSNKADKGPS CVRSPISTDE CSIQELEQKL LEREGALQKL QRSFEEKELA SSLAYEERPR RCRDELEGPE PKGGNKLKQA SQKSQRAQQV LHLQVLQLQQ EKRQLRQELE SLMKEQDLLE TKLRSYEREK TSFGPALEET QWEVCQKSGE ISLLKQQLKE SQTEVNAKAS EILGLKAQLK DTRGKLEGLE LRTQDLEGAL RTKGLELEVC ENELQRKKNE AELLREKVNL LEQELQELRA QAALARDMGP PTFPEDVPAL QRELERLRAE LREERQGHDQ MSSGFQHERL VWKEEKEKVI QYQKQLQQSY VAMYQRNQRL EKALQQLARG DSAGEPLEVD LEGADIPYED IIATEI
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