About Heparanase
Heparanase (HPSE) is a protein
from Homo sapiens identified by UniProt accession
Q9Y251, 543 residues long.
MolForge cross-references it against 0 known binders and
507 disease associations.
Target properties
| Protein name | Heparanase |
|---|
| UniProt accession | Q9Y251 |
|---|
| Gene | HPSE |
|---|
| Organism | Homo sapiens |
|---|
| Length | 543 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Approved drugs hitting this target (3)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (507)
Diseases linked to this target (Open Targets).
- blood protein measurement · score 0.44
- hepatocellular carcinoma · score 0.36
- neoplasm · score 0.12
- monocyte count · score 0.11
- multiple myeloma · score 0.10
- breast cancer · score 0.10
- alkaline phosphatase measurement · score 0.10
- cancer · score 0.09
- gonorrhea · score 0.09
- oral squamous cell carcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y251-F1 | alphafold | PREDICTED | 94.70 | — |
Amino-acid sequence (543 residues)
MLLRSKPALP PPLMLLLLGP LGPLSPGALP RPAQAQDVVD LDFFTQEPLH LVSPSFLSVT IDANLATDPR FLILLGSPKL RTLARGLSPA YLRFGGTKTD FLIFDPKKES TFEERSYWQS QVNQDICKYG SIPPDVEEKL RLEWPYQEQL LLREHYQKKF KNSTYSRSSV DVLYTFANCS GLDLIFGLNA LLRTADLQWN SSNAQLLLDY CSSKGYNISW ELGNEPNSFL KKADIFINGS QLGEDFIQLH KLLRKSTFKN AKLYGPDVGQ PRRKTAKMLK SFLKAGGEVI DSVTWHHYYL NGRTATKEDF LNPDVLDIFI SSVQKVFQVV ESTRPGKKVW LGETSSAYGG GAPLLSDTFA AGFMWLDKLG LSARMGIEVV MRQVFFGAGN YHLVDENFDP LPDYWLSLLF KKLVGTKVLM ASVQGSKRRK LRVYLHCTNT DNPRYKEGDL TLYAINLHNV TKYLRLPYPF SNKQVDKYLL RPLGPHGLLS KSVQLNGLTL KMVDDQTLPP LMEKPLRPGS SLGLPAFSYS FFVIRNAKVA ACI
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