CAAX prenyl protease 2 (RCE1)

About CAAX prenyl protease 2

CAAX prenyl protease 2 (RCE1) is a protein from Homo sapiens identified by UniProt accession Q9Y256, 329 residues long. MolForge cross-references it against 0 known binders and 38 disease associations.

Target properties

Protein name	CAAX prenyl protease 2
UniProt accession	Q9Y256
Gene	RCE1
Organism	Homo sapiens
Length	329 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Approved drugs hitting this target (2)

DrugCentral-linked approved drugs that act on this protein.

Disease associations (38)

Diseases linked to this target (Open Targets).

ovarian cancer · score 0.23
breast adenocarcinoma · score 0.23
colorectal carcinoma · score 0.07
neoplasm · score 0.04
hepatocellular carcinoma · score 0.04
chronotype measurement · score 0.03
diet measurement · score 0.03
coffee consumption · score 0.03
risk-taking behaviour · score 0.03
self reported educational attainment · score 0.03

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y256-F1	alphafold	PREDICTED	85.11	—

Amino-acid sequence (329 residues)

MAALGGDGLR LLSVSRPERP PESAALGGLG PGLCCWVSVF SCLSLACSYV GSLYVWKSEL PRDHPAVIKR RFTSVLVVSS LSPLCVLLWR ELTGIQPGTS LLTLMGFRLE GIFPAALLPL LLTMILFLGP LMQLSMDCPC DLADGLKVVL APRSWARCLT DMRWLRNQVI APLTEELVFR ACMLPMLAPC MGLGPAVFTC PLFFGVAHFH HIIEQLRFRQ SSVGNIFLSA AFQFSYTAVF GAYTAFLFIR TGHLIGPVLC HSFCNYMGFP AVCAALEHPQ RRPLLAGYAL GVGLFLLLLQ PLTDPKLYGS LPLCVLLERA GDSEAPLCS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards