Potassium channel subfamily K member 6 (KCNK6)

About Potassium channel subfamily K member 6

Potassium channel subfamily K member 6 (KCNK6) is a protein from Homo sapiens identified by UniProt accession Q9Y257, 313 residues long. MolForge cross-references it against 0 known binders and 85 disease associations.

Target properties

Protein name	Potassium channel subfamily K member 6
UniProt accession	Q9Y257
Gene	KCNK6
Organism	Homo sapiens
Length	313 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (85)

Diseases linked to this target (Open Targets).

calcium measurement · score 0.34
blood phosphate measurement · score 0.34
neuroinflammatory disorder · score 0.32
lung adenocarcinoma · score 0.23
thyroid gland adenocarcinoma · score 0.18
cutaneous melanoma · score 0.16
Kunitz-type protease inhibitor 2 measurement · score 0.16
mean platelet volume · score 0.13
platelet component distribution width · score 0.08
hypertension · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y257-F1	alphafold	PREDICTED	82.82	—

Amino-acid sequence (313 residues)

MRRGALLAGA LAAYAAYLVL GALLVARLEG PHEARLRAEL ETLRAQLLQR SPCVAAPALD AFVERVLAAG RLGRVVLANA SGSANASDPA WDFASALFFA STLITTVGYG YTTPLTDAGK AFSIAFALLG VPTTMLLLTA SAQRLSLLLT HVPLSWLSMR WGWDPRRAAC WHLVALLGVV VTVCFLVPAV IFAHLEEAWS FLDAFYFCFI SLSTIGLGDY VPGEAPGQPY RALYKVLVTV YLFLGLVAMV LVLQTFRHVS DLHGLTELIL LPPPCPASFN ADEDDRVDIL GPQPESHQQL SASSHTDYAS IPR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards