Hepatocyte nuclear factor 3-beta (FOXA2)

About Hepatocyte nuclear factor 3-beta

Hepatocyte nuclear factor 3-beta (FOXA2) is a protein from Homo sapiens identified by UniProt accession Q9Y261, 457 residues long. MolForge cross-references it against 0 known binders and 320 disease associations.

Target properties

Protein name	Hepatocyte nuclear factor 3-beta
UniProt accession	Q9Y261
Gene	FOXA2
Organism	Homo sapiens
Length	457 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (320)

Diseases linked to this target (Open Targets).

glucose measurement · score 0.48
fasting blood glucose measurement · score 0.46
BMI-adjusted fasting blood glucose measurement · score 0.43
endometrial cancer · score 0.43
hypothyroidism · score 0.41
hyperinsulinism · score 0.37
hypopituitarism · score 0.37
congenital isolated hyperinsulinism · score 0.37
non-acquired combined pituitary hormone deficiency · score 0.37
familial hyperinsulinism · score 0.37

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y261-F1	alphafold	PREDICTED	56.69	—

Amino-acid sequence (457 residues)

MLGAVKMEGH EPSDWSSYYA EPEGYSSVSN MNAGLGMNGM NTYMSMSAAA MGSGSGNMSA GSMNMSSYVG AGMSPSLAGM SPGAGAMAGM GGSAGAAGVA GMGPHLSPSL SPLGGQAAGA MGGLAPYANM NSMSPMYGQA GLSRARDPKT YRRSYTHAKP PYSYISLITM AIQQSPNKML TLSEIYQWIM DLFPFYRQNQ QRWQNSIRHS LSFNDCFLKV PRSPDKPGKG SFWTLHPDSG NMFENGCYLR RQKRFKCEKQ LALKEAAGAA GSGKKAAAGA QASQAQLGEA AGPASETPAG TESPHSSASP CQEHKRGGLG ELKGTPAAAL SPPEPAPSPG QQQQAAAHLL GPPHHPGLPP EAHLKPEHHY AFNHPFSINN LMSSEQQHHH SHHHHQPHKM DLKAYEQVMH YPGYGSPMPG SLAMGPVTNK TGLDASPLAA DTSYYQGVYS RPIMNSS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards