About Eukaryotic translation initiation factor 3 subunit L
Eukaryotic translation initiation factor 3 subunit L (EIF3L) is a protein
from Homo sapiens identified by UniProt accession
Q9Y262, 564 residues long.
MolForge cross-references it against 0 known binders and
16 disease associations.
Target properties
| Protein name | Eukaryotic translation initiation factor 3 subunit L |
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| UniProt accession | Q9Y262 |
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| Gene | EIF3L |
|---|
| Organism | Homo sapiens |
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| Length | 564 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (16)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.50
- heel bone mineral density · score 0.06
- white matter microstructure measurement · score 0.04
- refractive error measurement · score 0.03
- platelet count · score 0.02
- infect · score 0.01
- infection · score 0.01
- breast ductal adenocarcinoma · score 0.01
- lung adenocarcinoma · score 0.01
- neoplasm · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y262-F1 | alphafold | PREDICTED | 68.79 | — |
Amino-acid sequence (564 residues)
MSYPADDYES EAAYDPYAYP SDYDMHTGDP KQDLAYERQY EQQTYQVIPE VIKNFIQYFH KTVSDLIDQK VYELQASRVS SDVIDQKVYE IQDIYENSWT KLTERFFKNT PWPEAEAIAP QVGNDAVFLI LYKELYYRHI YAKVSGGPSL EQRFESYYNY CNLFNYILNA DGPAPLELPN QWLWDIIDEF IYQFQSFSQY RCKTAKKSEE EIDFLRSNPK IWNVHSVLNV LHSLVDKSNI NRQLEVYTSG GDPESVAGEY GRHSLYKMLG YFSLVGLLRL HSLLGDYYQA IKVLENIELN KKSMYSRVPE CQVTTYYYVG FAYLMMRRYQ DAIRVFANIL LYIQRTKSMF QRTTYKYEMI NKQNEQMHAL LAIALTMYPM RIDESIHLQL REKYGDKMLR MQKGDPQVYE ELFSYSCPKF LSPVVPNYDN VHPNYHKEPF LQQLKVFSDE VQQQAQLSTI RSFLKLYTTM PVAKLAGFLD LTEQEFRIQL LVFKHKMKNL VWTSGISALD GEFQSASEVD FYIDKDMIHI ADTKVARRYG DFFIRQIHKF EELNRTLKKM GQRP
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