RuvB-like 1 (RUVBL1)

About RuvB-like 1

RuvB-like 1 (RUVBL1) is a protein from Homo sapiens identified by UniProt accession Q9Y265, 456 residues long. MolForge cross-references it against 0 known binders and 164 disease associations.

Target properties

Protein name	RuvB-like 1
UniProt accession	Q9Y265
Gene	RUVBL1
Organism	Homo sapiens
Length	456 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (164)

Diseases linked to this target (Open Targets).

Isolated polycystic liver disease · score 0.29
autosomal dominant polycystic liver disease · score 0.29
breast adenocarcinoma · score 0.27
glioblastoma multiforme · score 0.25
Red cell distribution width · score 0.22
genetic disorder · score 0.18
FEV/FVC ratio · score 0.17
eosinophil count · score 0.15
uterine prolapse · score 0.13
mean platelet volume · score 0.12

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y265-F1	alphafold	PREDICTED	87.54	—

Amino-acid sequence (456 residues)

MKIEEVKSTT KTQRIASHSH VKGLGLDESG LAKQAASGLV GQENAREACG VIVELIKSKK MAGRAVLLAG PPGTGKTALA LAIAQELGSK VPFCPMVGSE VYSTEIKKTE VLMENFRRAI GLRIKETKEV YEGEVTELTP CETENPMGGY GKTISHVIIG LKTAKGTKQL KLDPSIFESL QKERVEAGDV IYIEANSGAV KRQGRCDTYA TEFDLEAEEY VPLPKGDVHK KKEIIQDVTL HDLDVANARP QGGQDILSMM GQLMKPKKTE ITDKLRGEIN KVVNKYIDQG IAELVPGVLF VDEVHMLDIE CFTYLHRALE SSIAPIVIFA SNRGNCVIRG TEDITSPHGI PLDLLDRVMI IRTMLYTPQE MKQIIKIRAQ TEGINISEEA LNHLGEIGTK TTLRYSVQLL TPANLLAKIN GKDSIEKEHV EEISELFYDA KSSAKILADQ QDKYMK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards