About Solute carrier family 22 member 14
Solute carrier family 22 member 14 (SLC22A14) is a protein
from Homo sapiens identified by UniProt accession
Q9Y267, 594 residues long.
MolForge cross-references it against 0 known binders and
79 disease associations.
Target properties
| Protein name | Solute carrier family 22 member 14 |
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| UniProt accession | Q9Y267 |
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| Gene | SLC22A14 |
|---|
| Organism | Homo sapiens |
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| Length | 594 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (79)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.40
- Follicular Cyst · score 0.37
- azoospermia · score 0.09
- male infertility with teratozoospermia due to single gene mutation · score 0.08
- spermatogenic failure 65 · score 0.06
- spermatogenic failure 72 · score 0.06
- spermatogenic failure 56 · score 0.06
- spermatogenic failure 46 · score 0.06
- spermatogenic failure 18 · score 0.06
- spermatogenic failure 27 · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y267-F1 | alphafold | PREDICTED | 81.25 | — |
Amino-acid sequence (594 residues)
MAGEENFKEE LRSQDASRNL NQHEVAGHPH SWSLEMLLRR LRAVHTKQDD KFANLLDAVG EFGTFQQRLV ALTFIPSIMS AFFMFADHFV FTAQKPYCNT SWILAVGPHL SKAEQLNLTI PQAPNGSFLT CFMYLPVPWN LDSIIQFGLN DTDTCQDGWI YPDAKKRSLI NEFDLVCGME TKKDTAQIMF MAGLPIGSLI FRLITDKMGR YPAILLSLLG LIIFGFGTAF MNSFHLYLFF RFGISQSVVG YAISSISLAT EWLVGEHRAH AIILGHCFFA VGAVLLTGIA YSLPHWQLLF LVGGILVIPF ISYIWILPES PRWLMMKGKV KEAKQVLCYA ASVNKKTIPS NLLDELQLPR KKVTRASVLD FCKNRQLCKV TLVMSCVWFT VSYTYFTLSL RMRELGVSVH FRHVVPSIME VPARLCCIFL LQQIGRKWSL AVTLLQAIIW CLLLLFLPEG EDGLRLKWPR CPATELKSMT ILVLMLREFS LAATVTVFFL YTAELLPTVL RATGLGLVSL ASVAGAILSL TIISQTPSLL PIFLCCVLAI VAFSLSSLLP ETRDQPLSES LNHSSQIRNK VKDMKTKETS SDDV
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