Non-selective voltage-gated ion channel VDAC3 (VDAC3)

About Non-selective voltage-gated ion channel VDAC3

Non-selective voltage-gated ion channel VDAC3 (VDAC3) is a protein from Homo sapiens identified by UniProt accession Q9Y277, 283 residues long. MolForge cross-references it against 0 known binders and 148 disease associations.

Target properties

Protein name	Non-selective voltage-gated ion channel VDAC3
UniProt accession	Q9Y277
Gene	VDAC3
Organism	Homo sapiens
Length	283 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (148)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.53
low grade glioma · score 0.23
mean reticulocyte volume · score 0.12
azoospermia · score 0.10
hematological measurement · score 0.09
mean corpuscular volume · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.09
lymphatic system disease · score 0.09
spermatogenic failure 72 · score 0.08
spermatogenic failure 65 · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y277-F1	alphafold	PREDICTED	95.13	—

Amino-acid sequence (283 residues)

MCNTPTYCDL GKAAKDVFNK GYGFGMVKID LKTKSCSGVE FSTSGHAYTD TGKASGNLET KYKVCNYGLT FTQKWNTDNT LGTEISWENK LAEGLKLTLD TIFVPNTGKK SGKLKASYKR DCFSVGSNVD IDFSGPTIYG WAVLAFEGWL AGYQMSFDTA KSKLSQNNFA LGYKAADFQL HTHVNDGTEF GGSIYQKVNE KIETSINLAW TAGSNNTRFG IAAKYMLDCR TSLSAKVNNA SLIGLGYTQT LRPGVKLTLS ALIDGKNFSA GGHKVGLGFE LEA

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards