About Heparan sulfate glucosamine 3-O-sulfotransferase 2
Heparan sulfate glucosamine 3-O-sulfotransferase 2 (HS3ST2) is a protein
from Homo sapiens identified by UniProt accession
Q9Y278, 367 residues long.
MolForge cross-references it against 0 known binders and
52 disease associations.
Target properties
| Protein name | Heparan sulfate glucosamine 3-O-sulfotransferase 2 |
|---|
| UniProt accession | Q9Y278 |
|---|
| Gene | HS3ST2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 367 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (52)
Diseases linked to this target (Open Targets).
- PHF-tau measurement · score 0.32
- systemic lupus erythematosus · score 0.06
- hepatocellular carcinoma · score 0.06
- 3-hydroxypropylmercapturic acid measurement · score 0.05
- Tetralogy of Fallot · score 0.03
- non-small cell lung carcinoma · score 0.02
- gastric adenocarcinoma · score 0.02
- neoplasm · score 0.02
- glioblastoma multiforme · score 0.02
- astrocytoma · score 0.01
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y278-F1 | alphafold | PREDICTED | 82.73 | — |
Amino-acid sequence (367 residues)
MAYRVLGRAG PPQPRRARRL LFAFTLSLSC TYLCYSFLCC CDDLGRSRLL GAPRCLRGPS AGGQKLLQKS RPCDPSGPTP SEPSAPSAPA AAVPAPRLSG SNHSGSPKLG TKRLPQALIV GVKKGGTRAV LEFIRVHPDV RALGTEPHFF DRNYGRGLDW YRSLMPRTLE SQITLEKTPS YFVTQEAPRR IFNMSRDTKL IVVVRNPVTR AISDYTQTLS KKPDIPTFEG LSFRNRTLGL VDVSWNAIRI GMYVLHLESW LQYFPLAQIH FVSGERLITD PAGEMGRVQD FLGIKRFITD KHFYFNKTKG FPCLKKTESS LLPRCLGKSK GRTHVQIDPE VIDQLREFYR PYNIKFYETV GQDFRWE
Explore Heparan sulfate glucosamine 3-O-sulfotransferase 2 with MolForge
Find binders, run structure-based screening, and map this target across
diseases and approved drugs with our AI-powered platform.
Browse all targets