About V-set and immunoglobulin domain-containing protein 4
V-set and immunoglobulin domain-containing protein 4 (VSIG4) is a protein
from Homo sapiens identified by UniProt accession
Q9Y279, 399 residues long.
MolForge cross-references it against 0 known binders and
207 disease associations.
Target properties
| Protein name | V-set and immunoglobulin domain-containing protein 4 |
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| UniProt accession | Q9Y279 |
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| Gene | VSIG4 |
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| Organism | Homo sapiens |
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| Length | 399 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (207)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.46
- serum albumin measurement · score 0.17
- high density lipoprotein cholesterol measurement · score 0.15
- neoplasm · score 0.10
- glioblastoma multiforme · score 0.09
- hepatocellular carcinoma · score 0.08
- acute myocardial infarction · score 0.08
- Immunodeficiency due to a late component of complements deficiency · score 0.07
- cancer · score 0.07
- experimental autoimmune encephalomyelitis · score 0.05
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y279-F1 | alphafold | PREDICTED | 74.08 | — |
Amino-acid sequence (399 residues)
MGILLGLLLL GHLTVDTYGR PILEVPESVT GPWKGDVNLP CTYDPLQGYT QVLVKWLVQR GSDPVTIFLR DSSGDHIQQA KYQGRLHVSH KVPGDVSLQL STLEMDDRSH YTCEVTWQTP DGNQVVRDKI TELRVQKLSV SKPTVTTGSG YGFTVPQGMR ISLQCQARGS PPISYIWYKQ QTNNQEPIKV ATLSTLLFKP AVIADSGSYF CTAKGQVGSE QHSDIVKFVV KDSSKLLKTK TEAPTTMTYP LKATSTVKQS WDWTTDMDGY LGETSAGPGK SLPVFAIILI ISLCCMVVFT MAYIMLCRKT SQQEHVYEAA RAHAREANDS GETMRVAIFA SGCSSDEPTS QNLGNNYSDE PCIGQEYQII AQINGNYARL LDTVPLDYEF LATEGKSVC
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