About Cofilin-2
Cofilin-2 (CFL2) is a protein
from Homo sapiens identified by UniProt accession
Q9Y281, 166 residues long.
MolForge cross-references it against 0 known binders and
228 disease associations.
Target properties
| Protein name | Cofilin-2 |
|---|
| UniProt accession | Q9Y281 |
|---|
| Gene | CFL2 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 166 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
|---|
Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (228)
Diseases linked to this target (Open Targets).
- nemaline myopathy 7 · score 0.77
- serum alanine aminotransferase measurement · score 0.45
- aspartate aminotransferase measurement · score 0.41
- atrial fibrillation · score 0.41
- typical nemaline myopathy · score 0.37
- low density lipoprotein cholesterol measurement · score 0.31
- cardiac edema · score 0.30
- atrial flutter · score 0.30
- PHF-tau measurement · score 0.28
- waist-hip ratio · score 0.25
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y281-F1 | alphafold | PREDICTED | 88.46 | — |
Amino-acid sequence (166 residues)
MASGVTVNDE VIKVFNDMKV RKSSTQEEIK KRKKAVLFCL SDDKRQIIVE EAKQILVGDI GDTVEDPYTS FVKLLPLNDC RYALYDATYE TKESKKEDLV FIFWAPESAP LKSKMIYASS KDAIKKKFTG IKHEWQVNGL DDIKDRSTLG EKLGGNVVVS LEGKPL
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