About Endoplasmic reticulum-Golgi intermediate compartment protein 3
Endoplasmic reticulum-Golgi intermediate compartment protein 3 (ERGIC3) is a protein
from Homo sapiens identified by UniProt accession
Q9Y282, 383 residues long.
MolForge cross-references it against 0 known binders and
47 disease associations.
Target properties
| Protein name | Endoplasmic reticulum-Golgi intermediate compartment protein 3 |
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| UniProt accession | Q9Y282 |
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| Gene | ERGIC3 |
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| Organism | Homo sapiens |
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| Length | 383 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (47)
Diseases linked to this target (Open Targets).
- total cholesterol measurement · score 0.22
- low density lipoprotein cholesterol measurement · score 0.19
- Intellectual disability · score 0.18
- bilirubin measurement · score 0.14
- interleukin-27 measurement · score 0.09
- hepatocellular carcinoma · score 0.08
- refractive error · score 0.07
- non-small cell lung carcinoma · score 0.07
- triglyceride measurement · score 0.06
- hypertrophic cardiomyopathy · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y282-F1 | alphafold | PREDICTED | 83.91 | — |
Amino-acid sequence (383 residues)
MEALGKLKQF DAYPKTLEDF RVKTCGGATV TIVSGLLMLL LFLSELQYYL TTEVHPELYV DKSRGDKLKI NIDVLFPHMP CAYLSIDAMD VAGEQQLDVE HNLFKQRLDK DGIPVSSEAE RHELGKVEVT VFDPDSLDPD RCESCYGAEA EDIKCCNTCE DVREAYRRRG WAFKNPDTIE QCRREGFSQK MQEQKNEGCQ VYGFLEVNKV AGNFHFAPGK SFQQSHVHVH DLQSFGLDNI NMTHYIQHLS FGEDYPGIVN PLDHTNVTAP QASMMFQYFV KVVPTVYMKV DGEVLRTNQF SVTRHEKVAN GLLGDQGLPG VFVLYELSPM MVKLTEKHRS FTHFLTGVCA IIGGMFTVAG LIDSLIYHSA RAIQKKIDLG KTT
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