About Phenylalanine--tRNA ligase alpha subunit
Phenylalanine--tRNA ligase alpha subunit (FARSA) is a protein
from Homo sapiens identified by UniProt accession
Q9Y285, 508 residues long.
MolForge cross-references it against 0 known binders and
69 disease associations.
Target properties
| Protein name | Phenylalanine--tRNA ligase alpha subunit |
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| UniProt accession | Q9Y285 |
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| Gene | FARSA |
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| Organism | Homo sapiens |
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| Length | 508 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (69)
Diseases linked to this target (Open Targets).
- Rajab interstitial lung disease with brain calcifications 2 · score 0.61
- alcohol consumption measurement · score 0.11
- type 2 diabetes mellitus · score 0.10
- mean corpuscular volume · score 0.10
- diabetes mellitus · score 0.10
- mean corpuscular hemoglobin · score 0.10
- glomerular filtration rate · score 0.09
- erythrocyte count · score 0.09
- body height · score 0.08
- Mantle cell lymphoma · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y285-F1 | alphafold | PREDICTED | 88.08 | — |
Amino-acid sequence (508 residues)
MADGQVAELL LRRLEASDGG LDSAELAAEL GMEHQAVVGA VKSLQALGEV IEAELRSTKH WELTAEGEEI AREGSHEARV FRSIPPEGLA QSELMRLPSG KVGFSKAMSN KWIRVDKSAA DGPRVFRVVD SMEDEVQRRL QLVRGGQAEK LGEKERSELR KRKLLAEVTL KTYWVSKGSA FSTSISKQET ELSPEMISSG SWRDRPFKPY NFLAHGVLPD SGHLHPLLKV RSQFRQIFLE MGFTEMPTDN FIESSFWNFD ALFQPQQHPA RDQHDTFFLR DPAEALQLPM DYVQRVKRTH SQGGYGSQGY KYNWKLDEAR KNLLRTHTTS ASARALYRLA QKKPFTPVKY FSIDRVFRNE TLDATHLAEF HQIEGVVADH GLTLGHLMGV LREFFTKLGI TQLRFKPAYN PYTEPSMEVF SYHQGLKKWV EVGNSGVFRP EMLLPMGLPE NVSVIAWGLS LERPTMIKYG INNIRELVGH KVNLQMVYDS PLCRLDAEPR PPPTQEAA
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