Sialic acid-binding Ig-like lectin 7 (SIGLEC7)

About Sialic acid-binding Ig-like lectin 7

Sialic acid-binding Ig-like lectin 7 (SIGLEC7) is a protein from Homo sapiens identified by UniProt accession Q9Y286, 467 residues long. MolForge cross-references it against 0 known binders and 95 disease associations.

Target properties

Protein name	Sialic acid-binding Ig-like lectin 7
UniProt accession	Q9Y286
Gene	SIGLEC7
Organism	Homo sapiens
Length	467 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (95)

Diseases linked to this target (Open Targets).

reticulocyte measurement · score 0.23
blood protein measurement · score 0.22
neurodegenerative disease · score 0.20
cerebrospinal fluid biomarker measurement · score 0.19
neoplasm · score 0.09
neutrophil immunodeficiency syndrome · score 0.08
Miyoshi myopathy · score 0.07
chronic lymphocytic leukemia · score 0.07
non-alcoholic fatty liver disease · score 0.07
type 2 diabetes mellitus · score 0.05

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y286-F1	alphafold	PREDICTED	74.27	—

Amino-acid sequence (467 residues)

MLLLLLLPLL WGRERVEGQK SNRKDYSLTM QSSVTVQEGM CVHVRCSFSY PVDSQTDSDP VHGYWFRAGN DISWKAPVAT NNPAWAVQEE TRDRFHLLGD PQTKNCTLSI RDARMSDAGR YFFRMEKGNI KWNYKYDQLS VNVTALTHRP NILIPGTLES GCFQNLTCSV PWACEQGTPP MISWMGTSVS PLHPSTTRSS VLTLIPQPQH HGTSLTCQVT LPGAGVTTNR TIQLNVSYPP QNLTVTVFQG EGTASTALGN SSSLSVLEGQ SLRLVCAVDS NPPARLSWTW RSLTLYPSQP SNPLVLELQV HLGDEGEFTC RAQNSLGSQH VSLNLSLQQE YTGKMRPVSG VLLGAVGGAG ATALVFLSFC VIFIVVRSCR KKSARPAADV GDIGMKDANT IRGSASQGNL TESWADDNPR HHGLAAHSSG EEREIQYAPL SFHKGEPQDL SGQEATNNEY SEIKIPK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards