About Integral membrane protein 2B
Integral membrane protein 2B (ITM2B) is a protein
from Homo sapiens identified by UniProt accession
Q9Y287, 266 residues long.
MolForge cross-references it against 0 known binders and
92 disease associations.
Target properties
| Protein name | Integral membrane protein 2B |
|---|
| UniProt accession | Q9Y287 |
|---|
| Gene | ITM2B |
|---|
| Organism | Homo sapiens |
|---|
| Length | 266 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (92)
Diseases linked to this target (Open Targets).
- ABri amyloidosis · score 0.72
- ADan amyloidosis · score 0.71
- retinal dystrophy with inner retinal dysfunction and ganglion cell anomalies · score 0.50
- AL amyloidosis · score 0.46
- retinoblastoma · score 0.34
- body height · score 0.24
- birth weight · score 0.23
- hematocrit · score 0.23
- genetic disorder · score 0.18
- hemoglobin measurement · score 0.18
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y287-F1 | alphafold | PREDICTED | 75.42 | — |
Amino-acid sequence (266 residues)
MVKVTFNSAL AQKEAKKDEP KSGEEALIIP PDAVAVDCKD PDDVVPVGQR RAWCWCMCFG LAFMLAGVIL GGAYLYKYFA LQPDDVYYCG IKYIKDDVIL NEPSADAPAA LYQTIEENIK IFEEEEVEFI SVPVPEFADS DPANIVHDFN KKLTAYLDLN LDKCYVIPLN TSIVMPPRNL LELLINIKAG TYLPQSYLIH EHMVITDRIE NIDHLGFFIY RLCHDKETYK LQRRETIKGI QKREASNCFA IRHFENKFAV ETLICS
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