Developmentally-regulated GTP-binding protein 1 (DRG1)

About Developmentally-regulated GTP-binding protein 1

Developmentally-regulated GTP-binding protein 1 (DRG1) is a protein from Homo sapiens identified by UniProt accession Q9Y295, 367 residues long. MolForge cross-references it against 0 known binders and 49 disease associations.

Target properties

Protein name	Developmentally-regulated GTP-binding protein 1
UniProt accession	Q9Y295
Gene	DRG1
Organism	Homo sapiens
Length	367 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (49)

Diseases linked to this target (Open Targets).

Tan-Almurshedi syndrome · score 0.47
Flexion contracture · score 0.26
Neurodevelopmental disorder · score 0.12
leukocyte count · score 0.11
neutrophil count · score 0.11
myeloid white cell count · score 0.08
sum of basophil and neutrophil counts · score 0.08
osteosarcoma · score 0.07
melanoma · score 0.07
reticulocyte count · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y295-F1	alphafold	PREDICTED	83.87	—

Amino-acid sequence (367 residues)

MSSTLAKIAE IEAEMARTQK NKATAHHLGL LKARLAKLRR ELITPKGGGG GGPGEGFDVA KTGDARIGFV GFPSVGKSTL LSNLAGVYSE VAAYEFTTLT TVPGVIRYKG AKIQLLDLPG IIEGAKDGKG RGRQVIAVAR TCNLILIVLD VLKPLGHKKI IENELEGFGI RLNSKPPNIG FKKKDKGGIN LTATCPQSEL DAETVKSILA EYKIHNADVT LRSDATADDL IDVVEGNRVY IPCIYVLNKI DQISIEELDI IYKVPHCVPI SAHHRWNFDD LLEKIWDYLK LVRIYTKPKG QLPDYTSPVV LPYSRTTVED FCMKIHKNLI KEFKYALVWG LSVKHNPQKV GKDHTLEDED VIQIVKK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards