About Trafficking protein particle complex subunit 4
Trafficking protein particle complex subunit 4 (TRAPPC4) is a protein
from Homo sapiens identified by UniProt accession
Q9Y296, 219 residues long.
MolForge cross-references it against 0 known binders and
51 disease associations.
Target properties
| Protein name | Trafficking protein particle complex subunit 4 |
|---|
| UniProt accession | Q9Y296 |
|---|
| Gene | TRAPPC4 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 219 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (51)
Diseases linked to this target (Open Targets).
- neurodevelopmental disorder with epilepsy, spasticity, and brain atrophy · score 0.70
- Glycogen storage disease due to glucose-6-phosphatase deficiency · score 0.57
- Glycogen storage disease due to glucose-6-phosphatase deficiency type b · score 0.57
- glycogen storage disease Ib · score 0.52
- congenital disorder of glycosylation, type IIw · score 0.52
- genetic disorder · score 0.41
- complex neurodevelopmental disorder · score 0.37
- disorder of glycogen metabolism · score 0.34
- neurodevelopmental disorder with progressive microcephaly, spasticity, and brain anomalies · score 0.34
- congenital disorder of glycosylation · score 0.26
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y296-F1 | alphafold | PREDICTED | 90.61 | — |
Amino-acid sequence (219 residues)
MAIFSVYVVN KAGGLIYQLD SYAPRAEAEK TFSYPLDLLL KLHDERVLVA FGQRDGIRVG HAVLAINGMD VNGRYTADGK EVLEYLGNPA NYPVSIRFGR PRLTSNEKLM LASMFHSLFA IGSQLSPEQG SSGIEMLETD TFKLHCYQTL TGIKFVVLAD PRQAGIDSLL RKIYEIYSDF ALKNPFYSLE MPIRCELFDQ NLKLALEVAE KAGTFGPGS
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