Nuclease EXOG, mitochondrial (EXOG)

About Nuclease EXOG, mitochondrial

Nuclease EXOG, mitochondrial (EXOG) is a protein from Homo sapiens identified by UniProt accession Q9Y2C4, 368 residues long. MolForge cross-references it against 0 known binders and 36 disease associations.

Target properties

Protein name	Nuclease EXOG, mitochondrial
UniProt accession	Q9Y2C4
Gene	EXOG
Organism	Homo sapiens
Length	368 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (36)

Diseases linked to this target (Open Targets).

electrocardiography · score 0.44
glomerular filtration rate · score 0.37
creatinine measurement · score 0.35
QRS duration · score 0.34
Brugada syndrome · score 0.31
QT interval · score 0.28
disorder of pilosebaceous unit · score 0.27
lean body mass · score 0.25
Epidermal Inclusion Cyst · score 0.25
fat body mass · score 0.21

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y2C4-F1	alphafold	PREDICTED	88.01	—

Amino-acid sequence (368 residues)

MAIKSIASRL RGSRRFLSGF VAGAVVGAAG AGLAALQFFR SQGAEGALTG KQPDGSAEKA VLEQFGFPLT GTEARCYTNH ALSYDQAKRV PRWVLEHISK SKIMGDADRK HCKFKPDPNI PPTFSAFNED YVGSGWSRGH MAPAGNNKFS SKAMAETFYL SNIVPQDFDN NSGYWNRIEM YCRELTERFE DVWVVSGPLT LPQTRGDGKK IVSYQVIGED NVAVPSHLYK VILARRSSVS TEPLALGAFV VPNEAIGFQP QLTEFQVSLQ DLEKLSGLVF FPHLDRTSDI RNICSVDTCK LLDFQEFTLY LSTRKIEGAR SVLRLEKIME NLKNAEIEPD DYFMSRYEKK LEELKAKEQS GTQIRKPS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards