Probable small intestine urate exporter (SLC17A4)

About Probable small intestine urate exporter

Probable small intestine urate exporter (SLC17A4) is a protein from Homo sapiens identified by UniProt accession Q9Y2C5, 497 residues long. MolForge cross-references it against 0 known binders and 70 disease associations.

Target properties

Protein name	Probable small intestine urate exporter
UniProt accession	Q9Y2C5
Gene	SLC17A4
Organism	Homo sapiens
Length	497 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (70)

Diseases linked to this target (Open Targets).

urinary metabolite measurement · score 0.32
mean corpuscular hemoglobin · score 0.25
schizophrenia · score 0.21
forced expiratory volume · score 0.17
mean corpuscular volume · score 0.15
alkaline phosphatase measurement · score 0.14
gout · score 0.14
response to tenofovir · score 0.10
eosinophil count · score 0.08
urate measurement · score 0.08

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y2C5-F1	alphafold	PREDICTED	83.69	—

Amino-acid sequence (497 residues)

MSTGPDVKAT VGDISSDGNL NVAQEECSRK GFCSVRHGLA LILQLCNFSI YTQQMNLSIA IPAMVNNTAP PSQPNASTER PSTDSQGYWN ETLKEFKAMA PAYDWSPEIQ GIILSSLNYG SFLAPIPSGY VAGIFGAKYV VGAGLFISSF LTLFIPLAAN AGVALLIVLR IVQGIAQVMV LTGQYSIWVK WAPPLERSQL TTIAGSGSML GSFIVLLAGG LLCQTIGWPY VFYIFGGIGC ACCPLWFPLI YDDPVNHPFI SAGEKRYIVC SLAQQDCSPG WSLPIRAMIK SLPLWAILVS YFCEYWLFYT IMAYTPTYIS SVLQANLRDS GILSALPFVV GCICIILGGL LADFLLSRKI LRLITIRKLF TAIGVLFPSV ILVSLPWVRS SHSMTMTFLV LSSAISSFCE SGALVNFLDI APRYTGFLKG LLQVFAHIAG AISPTAAGFF ISQDSEFGWR NVFLLSAAVN ISGLVFYLIF GRADVQDWAK EQTFTHL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards