About Exocyst complex component 6B
Exocyst complex component 6B (EXOC6B) is a protein
from Homo sapiens identified by UniProt accession
Q9Y2D4, 811 residues long.
MolForge cross-references it against 0 known binders and
49 disease associations.
Target properties
| Protein name | Exocyst complex component 6B |
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| UniProt accession | Q9Y2D4 |
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| Gene | EXOC6B |
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| Organism | Homo sapiens |
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| Length | 811 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
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Disease associations (49)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.54
- spondyloepimetaphyseal dysplasia with joint laxity · score 0.43
- diastolic blood pressure · score 0.29
- genetic disorder · score 0.27
- platelet crit · score 0.23
- cortical surface area measurement · score 0.23
- diet measurement · score 0.20
- brain measurement · score 0.20
- body height · score 0.17
- platelet count · score 0.15
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y2D4-F1 | alphafold | PREDICTED | 79.90 | — |
Amino-acid sequence (811 residues)
MERGKMAEAE SLETAAEHER ILREIESTDT ACIGPTLRSV YDGEEHGRFM EKLETRIRNH DREIEKMCNF HYQGFVDSIT ELLKVRGEAQ KLKNQVTDTN RKLQHEGKEL VIAMEELKQC RLQQRNISAT VDKLMLCLPV LEMYSKLRDQ MKTKRHYPAL KTLEHLEHTY LPQVSHYRFC KVMVDNIPKL REEIKDVSMS DLKDFLESIR KHSDKIGETA MKQAQQQRNL DNIVLQQPRI GSKRKSKKDA YIIFDTEIES TSPKSEQDSG ILDVEDEEDD EEVPGAQDLV DFSPVYRCLH IYSVLGARET FENYYRKQRR KQARLVLQPP SNMHETLDGY RKYFNQIVGF FVVEDHILHT TQGLVNRAYI DELWEMALSK TIAALRTHSS YCSDPNLVLD LKNLIVLFAD TLQVYGFPVN QLFDMLLEIR DQYSETLLKK WAGIFRNILD SDNYSPIPVT SEEMYKKVVG QFPFQDIELE KQPFPKKFPF SEFVPKVYNQ IKEFIYACLK FSEDLHLSST EVDDMIRKST NLLLTRTLSN SLQNVIKRKN IGLTELVQII INTTHLEKSC KYLEEFITNI TNVLPETVHT TKLYGTTTFK DARHAAEEEI YTNLNQKIDQ FLQLADYDWM TGDLGNKASD YLVDLIAFLR STFAVFTHLP GKVAQTACMS ACKHLATSLM QLLLEAEVRQ LTLGALQQFN LDVRECEQFA RSGPVPGFQE DTLQLAFIDL RQLLDLFIQW DWSTYLADYG QPNCKYLRVN PVTALTLLEK MKDTSRKNNM FAQFRKNERD KQKLIDTVAK QLRGLISSHH S
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