About Caspase recruitment domain-containing protein 8
Caspase recruitment domain-containing protein 8 (CARD8) is a protein
from Homo sapiens identified by UniProt accession
Q9Y2G2, 537 residues long.
MolForge cross-references it against 0 known binders and
112 disease associations.
Target properties
| Protein name | Caspase recruitment domain-containing protein 8 |
|---|
| UniProt accession | Q9Y2G2 |
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| Gene | CARD8 |
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| Organism | Homo sapiens |
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| Length | 537 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
|---|
| Pocket score | — |
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| Max clinical phase | — |
|---|
Disease associations (112)
Diseases linked to this target (Open Targets).
- inflammatory bowel disease 30 · score 0.51
- HIV-1 infection · score 0.07
- non-small cell lung carcinoma · score 0.06
- platelet count · score 0.06
- body height · score 0.04
- infect · score 0.03
- infection · score 0.03
- Gout · score 0.03
- neoplasm · score 0.03
- platelet crit · score 0.02
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y2G2-F1 | alphafold | PREDICTED | 70.98 | — |
Amino-acid sequence (537 residues)
MEKKECPEKS SSSEEELPRR DSGSSRNIDA SKLIRLQGSR KLLVDNSIRE LQYTKTGIFF QAEACVTNDT VYRELPCVSE TLCDISHFFQ EDDETEAEPL LFRAVPECQL SGGDIPSVSE EQESSEGQDS GDICSEENQI VSSYASKVCF EIEEDYKNRQ FLGPEGNVDV ELIDKSTNRY SVWFPTAGWY LWSATGLGFL VRDEVTVTIA FGSWSQHLAL DLQHHEQWLV GGPLFDVTAE PEEAVAEIHL PHFISLQAGE VDVSWFLVAH FKNEGMVLEH PARVEPFYAV LESPSFSLMG ILLRIASGTR LSIPITSNTL IYYHPHPEDI KFHLYLVPSD ALLTKAIDDE EDRFHGVRLQ TSPPMEPLNF GSSYIVSNSA NLKVMPKELK LSYRSPGEIQ HFSKFYAGQM KEPIQLEITE KRHGTLVWDT EVKPVDLQLV AASAPPPFSG AAFVKENHRQ LQARMGDLKG VLDDLQDNEV LTENEKELVE QEKTRQSKNE ALLSMVEKKG DLALDVLFRS ISERDPYLVS YLRQQNL
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