About Tyrosine-protein phosphatase non-receptor type 22
Tyrosine-protein phosphatase non-receptor type 22 (PTPN22) is a protein
from Homo sapiens identified by UniProt accession
Q9Y2R2, 807 residues long.
MolForge cross-references it against 0 known binders and
544 disease associations.
Target properties
| Protein name | Tyrosine-protein phosphatase non-receptor type 22 |
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| UniProt accession | Q9Y2R2 |
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| Gene | PTPN22 |
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| Organism | Homo sapiens |
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| Length | 807 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (544)
Diseases linked to this target (Open Targets).
- rheumatoid arthritis · score 0.49
- type 1 diabetes mellitus · score 0.49
- systemic lupus erythematosus · score 0.45
- Vitiligo · score 0.42
- hypothyroidism · score 0.38
- Hashimoto's thyroiditis · score 0.38
- autoimmune disease · score 0.37
- diabetes mellitus · score 0.36
- lymphocyte count · score 0.35
- thyroid disease · score 0.35
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y2R2-F1 | alphafold | PREDICTED | 58.62 | — |
Amino-acid sequence (807 residues)
MDQREILQKF LDEAQSKKIT KEEFANEFLK LKRQSTKYKA DKTYPTTVAE KPKNIKKNRY KDILPYDYSR VELSLITSDE DSSYINANFI KGVYGPKAYI ATQGPLSTTL LDFWRMIWEY SVLIIVMACM EYEMGKKKCE RYWAEPGEMQ LEFGPFSVSC EAEKRKSDYI IRTLKVKFNS ETRTIYQFHY KNWPDHDVPS SIDPILELIW DVRCYQEDDS VPICIHCSAG CGRTGVICAI DYTWMLLKDG IIPENFSVFS LIREMRTQRP SLVQTQEQYE LVYNAVLELF KRQMDVIRDK HSGTESQAKH CIPEKNHTLQ ADSYSPNLPK STTKAAKMMN QQRTKMEIKE SSSFDFRTSE ISAKEELVLH PAKSSTSFDF LELNYSFDKN ADTTMKWQTK AFPIVGEPLQ KHQSLDLGSL LFEGCSNSKP VNAAGRYFNS KVPITRTKST PFELIQQRET KEVDSKENFS YLESQPHDSC FVEMQAQKVM HVSSAELNYS LPYDSKHQIR NASNVKHHDS SALGVYSYIP LVENPYFSSW PPSGTSSKMS LDLPEKQDGT VFPSSLLPTS STSLFSYYNS HDSLSLNSPT NISSLLNQES AVLATAPRID DEIPPPLPVR TPESFIVVEE AGEFSPNVPK SLSSAVKVKI GTSLEWGGTS EPKKFDDSVI LRPSKSVKLR SPKSELHQDR SSPPPPLPER TLESFFLADE DCMQAQSIET YSTSYPDTME NSTSSKQTLK TPGKSFTRSK SLKILRNMKK SICNSCPPNK PAESVQSNNS SSFLNFGFAN RFSKPKGPRN PPPTWNI
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