Lambda-crystallin homolog (CRYL1)

About Lambda-crystallin homolog

Lambda-crystallin homolog (CRYL1) is a protein from Homo sapiens identified by UniProt accession Q9Y2S2, 319 residues long. MolForge cross-references it against 0 known binders and 110 disease associations.

Target properties

Protein name	Lambda-crystallin homolog
UniProt accession	Q9Y2S2
Gene	CRYL1
Organism	Homo sapiens
Length	319 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (110)

Diseases linked to this target (Open Targets).

hearing loss, autosomal recessive · score 0.48
autosomal recessive nonsyndromic hearing loss 1B · score 0.42
monoclonal gammopathy · score 0.31
nonpapillary renal cell carcinoma · score 0.08
polycystic ovary syndrome · score 0.06
glucuronate measurement · score 0.06
neoplasm · score 0.05
lung adenocarcinoma · score 0.04
glioma · score 0.04
myocarditis · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y2S2-F1	alphafold	PREDICTED	96.42	—

Amino-acid sequence (319 residues)

MASSAAGCVV IVGSGVIGRS WAMLFASGGF QVKLYDIEQQ QIRNALENIR KEMKLLEQAG SLKGSLSVEE QLSLISGCPN IQEAVEGAMH IQECVPEDLE LKKKIFAQLD SIIDDRVILS SSTSCLMPSK LFAGLVHVKQ CIVAHPVNPP YYIPLVELVP HPETAPTTVD RTHALMKKIG QCPMRVQKEV AGFVLNRLQY AIISEAWRLV EEGIVSPSDL DLVMSEGLGM RYAFIGPLET MHLNAEGMLS YCDRYSEGIK HVLQTFGPIP EFSRATAEKV NQDMCMKVPD DPEHLAARRQ WRDECLMRLA KLKSQVQPQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards