AP-3 complex subunit mu-1 (AP3M1)

About AP-3 complex subunit mu-1

AP-3 complex subunit mu-1 (AP3M1) is a protein from Homo sapiens identified by UniProt accession Q9Y2T2, 418 residues long. MolForge cross-references it against 0 known binders and 35 disease associations.

Target properties

Protein name	AP-3 complex subunit mu-1
UniProt accession	Q9Y2T2
Gene	AP3M1
Organism	Homo sapiens
Length	418 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (35)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.39
Parkinson disease · score 0.36
Alzheimer disease · score 0.36
multiple sclerosis · score 0.36
lysosomal storage disease · score 0.36
head and neck squamous cell carcinoma · score 0.25
endometrial cancer · score 0.25
breast adenocarcinoma · score 0.25
urinary bladder cancer · score 0.24
systolic blood pressure · score 0.24

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y2T2-F1	alphafold	PREDICTED	91.85	—

Amino-acid sequence (418 residues)

MIHSLFLINC SGDIFLEKHW KSVVSQSVCD YFFEAQEKAA DVENVPPVIS TPHHYLISIY RDKLFFVSVI QTEVPPLFVI EFLHRVADTF QDYFGECSEA AIKDNVVIVY ELLEEMLDNG FPLATESNIL KELIKPPTIL RSVVNSITGS SNVGDTLPTG QLSNIPWRRA GVKYTNNEAY FDVVEEIDAI IDKSGSTVFA EIQGVIDACI KLSGMPDLSL SFMNPRLLDD VSFHPCIRFK RWESERVLSF IPPDGNFRLI SYRVSSQNLV AIPVYVKHSI SFKENSSCGR FDITIGPKQN MGKTIEGITV TVHMPKVVLN MNLTPTQGSY TFDPVTKVLT WDVGKITPQK LPSLKGLVNL QSGAPKPEEN PSLNIQFKIQ QLAISGLKVN RLDMYGEKYK PFKGVKYVTK AGKFQVRT

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards