About Mitogen-activated protein kinase kinase kinase 2
Mitogen-activated protein kinase kinase kinase 2 (MAP3K2) is a protein
from Homo sapiens identified by UniProt accession
Q9Y2U5, 619 residues long.
MolForge cross-references it against 0 known binders and
89 disease associations.
Target properties
| Protein name | Mitogen-activated protein kinase kinase kinase 2 |
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| UniProt accession | Q9Y2U5 |
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| Gene | MAP3K2 |
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| Organism | Homo sapiens |
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| Length | 619 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (15)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (89)
Diseases linked to this target (Open Targets).
- protein C measurement · score 0.38
- body height · score 0.31
- neurodegenerative disease · score 0.28
- self reported educational attainment · score 0.27
- anxiety · score 0.10
- panic disorder · score 0.10
- blood protein measurement · score 0.10
- neoplasm · score 0.08
- vitamin K-dependent protein C measurement · score 0.08
- hepatocellular carcinoma · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y2U5-F1 | alphafold | PREDICTED | 67.70 | — |
Amino-acid sequence (619 residues)
MDDQQALNSI MQDLAVLHKA SRPALSLQET RKAKSSSPKK QNDVRVKFEH RGEKRILQFP RPVKLEDLRS KAKIAFGQSM DLHYTNNELV IPLTTQDDLD KAVELLDRSI HMKSLKILLV INGSTQATNL EPLPSLEDLD NTVFGAERKK RLSIIGPTSR DRSSPPPGYI PDELHQVARN GSFTSINSEG EFIPESMDQM LDPLSLSSPE NSGSGSCPSL DSPLDGESYP KSRMPRAQSY PDNHQEFSDY DNPIFEKFGK GGTYPRRYHV SYHHQEYNDG RKTFPRARRT QGTSLRSPVS FSPTDHSLST SSGSSIFTPE YDDSRIRRRG SDIDNPTLTV MDISPPSRSP RAPTNWRLGK LLGQGAFGRV YLCYDVDTGR ELAVKQVQFD PDSPETSKEV NALECEIQLL KNLLHERIVQ YYGCLRDPQE KTLSIFMEYM PGGSIKDQLK AYGALTENVT RKYTRQILEG VHYLHSNMIV HRDIKGANIL RDSTGNVKLG DFGASKRLQT ICLSGTGMKS VTGTPYWMSP EVISGEGYGR KADIWSVACT VVEMLTEKPP WAEFEAMAAI FKIATQPTNP KLPPHVSDYT RDFLKRIFVE AKLRPSADEL LRHMFVHYH
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