About 5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial
5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial (MTO1) is a protein
from Homo sapiens identified by UniProt accession
Q9Y2Z2, 717 residues long.
MolForge cross-references it against 0 known binders and
147 disease associations.
Target properties
| Protein name | 5-taurinomethyluridine-[tRNA] synthase subunit MTO1, mitochondrial |
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| UniProt accession | Q9Y2Z2 |
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| Gene | MTO1 |
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| Organism | Homo sapiens |
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| Length | 717 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (147)
Diseases linked to this target (Open Targets).
- mitochondrial hypertrophic cardiomyopathy with lactic acidosis due to MTO1 deficiency · score 0.79
- neurodegenerative disease · score 0.55
- genetic disorder · score 0.51
- mitochondrial disease · score 0.37
- Global developmental delay · score 0.34
- Abnormal brain morphology · score 0.33
- Red cell distribution width · score 0.27
- mitochondrial oxidative phosphorylation disorder · score 0.27
- neoplasm · score 0.10
- hypertrophic cardiomyopathy · score 0.07
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y2Z2-F1 | alphafold | PREDICTED | 86.02 | — |
Amino-acid sequence (717 residues)
MFYFRGCGRW VAVSFTKQQF PLARLSSDSA APRTPHFDVI VIGGGHAGTE AATAAARCGS RTLLLTHRVD TIGQMSCNPS FGGIGKGHLM REVDALDGLC SRICDQSGVH YKVLNRRKGP AVWGLRAQID RKLYKQNMQK EILNTPLLTV QEGAVEDLIL TEPEPEHTGK CRVSGVVLVD GSTVYAESVI LTTGTFLRGM IVIGLETHPA GRLGDQPSIG LAQTLEKLGF VVGRLKTGTP PRIAKESINF SILNKHIPDN PSIPFSFTNE TVWIKPEDQL PCYLTHTNPR VDEIVLKNLH LNSHVKETTR GPRYCPSIES KVLRFPNRLH QVWLEPEGMD SDLIYPQGLS MTLPAELQEK MITCIRGLEK AKVIQPDGVL LLLPRMECNG AISAHHNLPL PGYGVQYDYL DPRQITPSLE THLVQRLFFA GQINGTTGYE EAAAQGVIAG INASLRVSRK PPFVVSRTEG YIGVLIDDLT TLGTSEPYRM FTSRVEFRLS LRPDNADSRL TLRGYKDAGC VSQQRYERAC WMKSSLEEGI SVLKSIEFLS SKWKKLIPEA SISTSRSLPV RALDVLKYEE VDMDSLAKAV PEPLKKYTKC RELAERLKIE ATYESVLFHQ LQEIKGVQQD EALQLPKDLD YLTIRDVSLS HEVREKLHFS RPQTIGAASR IPGVTPAAII NLLRFVKTTQ RRQSAMNESS KTDQYLCDAD RLQEREL
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