Acyl-coenzyme A thioesterase 9, mitochondrial (ACOT9)

About Acyl-coenzyme A thioesterase 9, mitochondrial

Acyl-coenzyme A thioesterase 9, mitochondrial (ACOT9) is a protein from Homo sapiens identified by UniProt accession Q9Y305, 439 residues long. MolForge cross-references it against 0 known binders and 14 disease associations.

Target properties

Protein name	Acyl-coenzyme A thioesterase 9, mitochondrial
UniProt accession	Q9Y305
Gene	ACOT9
Organism	Homo sapiens
Length	439 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (14)

Diseases linked to this target (Open Targets).

hepatocellular carcinoma · score 0.04
head and neck squamous cell carcinoma · score 0.01
neoplasm · score 0.01
oral squamous cell carcinoma · score 0.01
Obesity · score 0.01
non-alcoholic fatty liver disease · score 0.01
Ehlers-Danlos syndrome · score 0.01
non-alcoholic steatohepatitis · score 0.00
nonpapillary renal cell carcinoma · score 0.00
X-linked intellectual disability, Turner type · score 0.00

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y305-F1	alphafold	PREDICTED	85.00	—

Amino-acid sequence (439 residues)

MRRAALRLCA LGKGQLTPGR GLTQGPQNPK KQGIFHIHEV RDKLREIVGA STNWRDHVKA MEERKLLHSF LAKSQDGLPP RRMKDSYIEV LLPLGSEPEL REKYLTVQNT VRFGRILEDL DSLGVLICYM HNKIHSAKMS PLSIVTALVD KIDMCKKSLS PEQDIKFSGH VSWVGKTSME VKMQMFQLHG DEFCPVLDAT FVMVARDSEN KGPAFVNPLI PESPEEEELF RQGELNKGRR IAFSSTSLLK MAPSAEERTT IHEMFLSTLD PKTISFRSRV LPSNAVWMEN SKLKSLEICH PQERNIFNRI FGGFLMRKAY ELAWATACSF GGSRPFVVAV DDIMFQKPVE VGSLLFLSSQ VCFTQNNYIQ VRVHSEVASL QEKQHTTTNV FHFTFMSEKE VPLVFPKTYG ESMLYLDGQR HFNSMSGPAT LRKDYLVEP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards