Nitric oxide synthase-interacting protein (NOSIP)

About Nitric oxide synthase-interacting protein

Nitric oxide synthase-interacting protein (NOSIP) is a protein from Homo sapiens identified by UniProt accession Q9Y314, 301 residues long. MolForge cross-references it against 0 known binders and 151 disease associations.

Target properties

Protein name	Nitric oxide synthase-interacting protein
UniProt accession	Q9Y314
Gene	NOSIP
Organism	Homo sapiens
Length	301 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (151)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.37
hematocrit · score 0.20
hemoglobin measurement · score 0.19
cortical surface area measurement · score 0.18
erythrocyte count · score 0.18
schizophrenia · score 0.17
body height · score 0.17
red blood cell density measurement · score 0.17
total iron binding capacity · score 0.14
total blood protein measurement · score 0.13

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y314-F1	alphafold	PREDICTED	81.33	—

Amino-acid sequence (301 residues)

MTRHGKNCTA GAVYTYHEKK KDTAASGYGT QNIRLSRDAV KDFDCCCLSL QPCHDPVVTP DGYLYEREAI LEYILHQKKE IARQMKAYEK QRGTRREEQK ELQRAASQDH VRGFLEKESA IVSRPLNPFT AKALSGTSPD DVQPGPSVGP PSKDKDKVLP SFWIPSLTPE AKATKLEKPS RTVTCPMSGK PLRMSDLTPV HFTPLDSSVD RVGLITRSER YVCAVTRDSL SNATPCAVLR PSGAVVTLEC VEKLIRKDMV DPVTGDKLTD RDIIVLQRGG TGFAGSGVKL QAEKSRPVMQ A

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards