Deoxyribose-phosphate aldolase (DERA)

About Deoxyribose-phosphate aldolase

Deoxyribose-phosphate aldolase (DERA) is a protein from Homo sapiens identified by UniProt accession Q9Y315, 318 residues long. MolForge cross-references it against 0 known binders and 24 disease associations.

Target properties

Protein name	Deoxyribose-phosphate aldolase
UniProt accession	Q9Y315
Gene	DERA
Organism	Homo sapiens
Length	318 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (24)

Diseases linked to this target (Open Targets).

amyloid-beta measurement · score 0.26
self reported educational attainment · score 0.26
mathematical ability · score 0.26
cognitive function measurement · score 0.26
glaucoma · score 0.25
arterial stiffness measurement · score 0.22
alcohol drinking · score 0.10
blood protein measurement · score 0.07
mental process · score 0.02
astrocytoma · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y315-F1	alphafold	PREDICTED	96.00	—

Amino-acid sequence (318 residues)

MSAHNRGTEL DLSWISKIQV NHPAVLRRAE QIQARRTVKK EWQAAWLLKA VTFIDLTTLS GDDTSSNIQR LCYKAKYPIR EDLLKALNMH DKGITTAAVC VYPARVCDAV KALKAAGCNI PVASVAAGFP AGQTHLKTRL EEIRLAVEDG ATEIDVVINR SLVLTGQWEA LYDEIRQFRK ACGEAHLKTI LATGELGTLT NVYKASMIAM MAGSDFIKTS TGKETVNATF PVAIVMLRAI RDFFWKTGNK IGFKPAGGIR SAKDSLAWLS LVKEELGDEW LKPELFRIGA STLLSDIERQ IYHHVTGRYA AYHDLPMS

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards