Thioredoxin-related transmembrane protein 2 (TMX2)

About Thioredoxin-related transmembrane protein 2

Thioredoxin-related transmembrane protein 2 (TMX2) is a protein from Homo sapiens identified by UniProt accession Q9Y320, 296 residues long. MolForge cross-references it against 0 known binders and 71 disease associations.

Target properties

Protein name	Thioredoxin-related transmembrane protein 2
UniProt accession	Q9Y320
Gene	TMX2
Organism	Homo sapiens
Length	296 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (71)

Diseases linked to this target (Open Targets).

neurodevelopmental disorder with microcephaly, cortical malformations, and spasticity · score 0.76
neurodegenerative disease · score 0.29
Abnormality of the nervous system · score 0.27
genetic disorder · score 0.19
schizophrenia · score 0.13
heel bone mineral density · score 0.11
systolic blood pressure · score 0.11
neuroticism measurement · score 0.10
self reported educational attainment · score 0.10
mean corpuscular hemoglobin · score 0.10

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y320-F1	alphafold	PREDICTED	85.83	—

Amino-acid sequence (296 residues)

MAVLAPLIAL VYSVPRLSRW LAQPYYLLSA LLSAAFLLVR KLPPLCHGLP TQREDGNPCD FDWREVEILM FLSAIVMMKN RRSITVEQHI GNIFMFSKVA NTILFFRLDI RMGLLYITLC IVFLMTCKPP LYMGPEYIKY FNDKTIDEEL ERDKRVTWIV EFFANWSNDC QSFAPIYADL SLKYNCTGLN FGKVDVGRYT DVSTRYKVST SPLTKQLPTL ILFQGGKEAM RRPQIDKKGR AVSWTFSEEN VIREFNLNEL YQRAKKLSKA GDNIPEEQPV ASTPTTVSDG ENKKDK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards