About Zinc finger and BTB domain-containing protein 12
Zinc finger and BTB domain-containing protein 12 (ZBTB12) is a protein
from Homo sapiens identified by UniProt accession
Q9Y330, 459 residues long.
MolForge cross-references it against 0 known binders and
38 disease associations.
Target properties
| Protein name | Zinc finger and BTB domain-containing protein 12 |
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| UniProt accession | Q9Y330 |
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| Gene | ZBTB12 |
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| Organism | Homo sapiens |
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| Length | 459 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (38)
Diseases linked to this target (Open Targets).
- response to vaccine · score 0.11
- lean body mass · score 0.06
- low density lipoprotein cholesterol measurement · score 0.06
- total cholesterol measurement · score 0.06
- triglyceride measurement · score 0.06
- endometriosis · score 0.05
- coronary artery disease · score 0.05
- blood protein measurement · score 0.04
- visual perception measurement · score 0.03
- chronic hepatitis B virus infection · score 0.03
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y330-F1 | alphafold | PREDICTED | 55.94 | — |
Amino-acid sequence (459 residues)
MASGVEVLRF QLPGHEAATL RNMNQLRAEE RFCDVTIVAD SLKFRGHKVI LAACSPFLRD QFLLNPSSEL QVSLMHSARI VADLLLSCYT GALEFAVRDI VNYLTAASYL QMEHVVEKCR NALSQFIEPK IGLKEDGVSE ASLVSSISAT KSLLPPARTP KPAPKPPPPP PLPPPLLRPV KLEFPLDEDL ELKAEEEDED EDEDVSDICI VKVESALEVA HRLKPPGGLG GGLGIGGSVG GHLGELAQSS VPPSTVAPPQ GVVKACYSLS EDAEGEGLLL IPGGRASVGA TSGLVEAAAV AMAARGAGGS LGAGGSRGPL PGGFSGGNPL KNIKCTKCPE VFQGVEKLVF HMRAQHFIFM CPRCGKQFNH SSNLNRHMNV HRGVKSHSCG ICGKCFTQKS TLHDHLNLHS GARPYRCSYC DVRFAHKPAI RRHLKEQHGK TTAENVLEAS VAEINVLIR
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