U6 snRNA-associated Sm-like protein LSm2 (LSM2)

About U6 snRNA-associated Sm-like protein LSm2

U6 snRNA-associated Sm-like protein LSm2 (LSM2) is a protein from Homo sapiens identified by UniProt accession Q9Y333, 95 residues long. MolForge cross-references it against 0 known binders and 83 disease associations.

Target properties

Protein name	U6 snRNA-associated Sm-like protein LSm2
UniProt accession	Q9Y333
Gene	LSM2
Organism	Homo sapiens
Length	95 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (83)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.46
blood protein measurement · score 0.03
complement C4 measurement · score 0.03
severe malarial anemia · score 0.03
visual perception measurement · score 0.03
cutaneous melanoma · score 0.02
neoplasm · score 0.02
Cirrhosis · score 0.02
coronary artery disease · score 0.02
ulcerative colitis · score 0.02

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y333-F1	alphafold	PREDICTED	94.81	—

Amino-acid sequence (95 residues)

MLFYSFFKSL VGKDVVVELK NDLSICGTLH SVDQYLNIKL TDISVTDPEK YPHMLSVKNC FIRGSVVRYV QLPADEVDTQ LLQDAARKEA LQQKQ

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards