Sialic acid-binding Ig-like lectin 9 (SIGLEC9)

About Sialic acid-binding Ig-like lectin 9

Sialic acid-binding Ig-like lectin 9 (SIGLEC9) is a protein from Homo sapiens identified by UniProt accession Q9Y336, 463 residues long. MolForge cross-references it against 0 known binders and 125 disease associations.

Target properties

Protein name	Sialic acid-binding Ig-like lectin 9
UniProt accession	Q9Y336
Gene	SIGLEC9
Organism	Homo sapiens
Length	463 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (125)

Diseases linked to this target (Open Targets).

blood protein measurement · score 0.37
monocyte percentage of leukocytes · score 0.36
sialic acid-binding Ig-like lectin 9 measurement · score 0.33
monocyte count · score 0.31
cerebrospinal fluid biomarker measurement · score 0.28
protein measurement · score 0.27
CD5 measurement · score 0.27
body mass index · score 0.26
C-reactive protein measurement · score 0.26
granulocyte percentage of myeloid white cells · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y336-F1	alphafold	PREDICTED	73.42	—

Amino-acid sequence (463 residues)

MLLLLLPLLW GRERAEGQTS KLLTMQSSVT VQEGLCVHVP CSFSYPSHGW IYPGPVVHGY WFREGANTDQ DAPVATNNPA RAVWEETRDR FHLLGDPHTK NCTLSIRDAR RSDAGRYFFR MEKGSIKWNY KHHRLSVNVT ALTHRPNILI PGTLESGCPQ NLTCSVPWAC EQGTPPMISW IGTSVSPLDP STTRSSVLTL IPQPQDHGTS LTCQVTFPGA SVTTNKTVHL NVSYPPQNLT MTVFQGDGTV STVLGNGSSL SLPEGQSLRL VCAVDAVDSN PPARLSLSWR GLTLCPSQPS NPGVLELPWV HLRDAAEFTC RAQNPLGSQQ VYLNVSLQSK ATSGVTQGVV GGAGATALVF LSFCVIFVVV RSCRKKSARP AAGVGDTGIE DANAVRGSAS QGPLTEPWAE DSPPDQPPPA SARSSVGEGE LQYASLSFQM VKPWDSRGQE ATDTEYSEIK IHR

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards