About Kallikrein-5
Kallikrein-5 (KLK5) is a protein
from Homo sapiens identified by UniProt accession
Q9Y337, 293 residues long.
MolForge cross-references it against 0 known binders and
132 disease associations.
Target properties
| Protein name | Kallikrein-5 |
|---|
| UniProt accession | Q9Y337 |
|---|
| Gene | KLK5 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 293 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (132)
Diseases linked to this target (Open Targets).
- glioblastoma multiforme · score 0.23
- breast adenocarcinoma · score 0.22
- clear cell renal carcinoma · score 0.18
- neuroblastoma · score 0.13
- urinary bladder cancer · score 0.11
- squamous cell lung carcinoma · score 0.11
- endometrial cancer · score 0.10
- breast cancer · score 0.10
- neoplasm · score 0.10
- oral squamous cell carcinoma · score 0.09
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y337-F1 | alphafold | PREDICTED | 83.01 | — |
Amino-acid sequence (293 residues)
MATARPPWMW VLCALITALL LGVTEHVLAN NDVSCDHPSN TVPSGSNQDL GAGAGEDARS DDSSSRIING SDCDMHTQPW QAALLLRPNQ LYCGAVLVHP QWLLTAAHCR KKVFRVRLGH YSLSPVYESG QQMFQGVKSI PHPGYSHPGH SNDLMLIKLN RRIRPTKDVR PINVSSHCPS AGTKCLVSGW GTTKSPQVHF PKVLQCLNIS VLSQKRCEDA YPRQIDDTMF CAGDKAGRDS CQGDSGGPVV CNGSLQGLVS WGDYPCARPN RPGVYTNLCK FTKWIQETIQ ANS
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