Intraflagellar transport protein 52 homolog (IFT52)

About Intraflagellar transport protein 52 homolog

Intraflagellar transport protein 52 homolog (IFT52) is a protein from Homo sapiens identified by UniProt accession Q9Y366, 437 residues long. MolForge cross-references it against 0 known binders and 42 disease associations.

Target properties

Protein name	Intraflagellar transport protein 52 homolog
UniProt accession	Q9Y366
Gene	IFT52
Organism	Homo sapiens
Length	437 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (42)

Diseases linked to this target (Open Targets).

short rib-polydactyly syndrome · score 0.73
cranioectodermal dysplasia · score 0.37
reticulocyte count · score 0.22
type 2 diabetes mellitus · score 0.22
mean corpuscular volume · score 0.20
reticulocyte measurement · score 0.19
myeloid white cell count · score 0.19
mean corpuscular hemoglobin · score 0.14
mean reticulocyte volume · score 0.12
Jeune syndrome · score 0.11

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y366-F1	alphafold	PREDICTED	84.24	—

Amino-acid sequence (437 residues)

MEKELRSTIL FNAYKKEIFT TNNGYKSMQK KLRSNWKIQS LKDEITSEKL NGVKLWITAG PREKFTAAEF EILKKYLDTG GDVFVMLGEG GESRFDTNIN FLLEEYGIMV NNDAVVRNVY HKYFHPKEAL VSSGVLNREI SRAAGKAVPG IIDEESSGNN AQALTFVYPF GATLSVMKPA VAVLSTGSVC FPLNRPILAF YHSKNQGGKL AVLGSCHMFS DQYLDKEENS KIMDVVFQWL TTGDIHLNQI DAEDPEISDY MMLPYTATLS KRNRECLQES DEIPRDFTTL FDLSIFQLDT TSFHSVIEAH EQLNVKHEPL QLIQPQFETP LPTLQPAVFP PSFRELPPPP LELFDLDETF SSEKARLAQI TNKCTEEDLE FYVRKCGDIL GVTSKLPKDQ QDAKHILEHV FFQVVEFKKL NQEHDIDTSE TAFQNNF

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards