Ubiquitin-conjugating enzyme E2 J1 (UBE2J1)

About Ubiquitin-conjugating enzyme E2 J1

Ubiquitin-conjugating enzyme E2 J1 (UBE2J1) is a protein from Homo sapiens identified by UniProt accession Q9Y385, 318 residues long. MolForge cross-references it against 0 known binders and 117 disease associations.

Target properties

Protein name	Ubiquitin-conjugating enzyme E2 J1
UniProt accession	Q9Y385
Gene	UBE2J1
Organism	Homo sapiens
Length	318 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (117)

Diseases linked to this target (Open Targets).

clear cell renal carcinoma · score 0.18
azoospermia · score 0.09
male infertility with teratozoospermia due to single gene mutation · score 0.07
spermatogenic failure 65 · score 0.06
partial chromosome Y deletion · score 0.06
spermatogenic failure 72 · score 0.06
spermatogenic failure 56 · score 0.06
spermatogenic failure 46 · score 0.06
spermatogenic failure 18 · score 0.06
spermatogenic failure 27 · score 0.06

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y385-F1	alphafold	PREDICTED	77.22	—

Amino-acid sequence (318 residues)

METRYNLKSP AVKRLMKEAA ELKDPTDHYH AQPLEDNLFE WHFTVRGPPD SDFDGGVYHG RIVLPPEYPM KPPSIILLTA NGRFEVGKKI CLSISGHHPE TWQPSWSIRT ALLAIIGFMP TKGEGAIGSL DYTPEERRAL AKKSQDFCCE GCGSAMKDVL LPLKSGSDSS QADQEAKELA RQISFKAEVN SSGKTISESD LNHSFSLTDL QDDIPTTFQG ATASTSYGLQ NSSAASFHQP TQPVAKNTSM SPRQRRAQQQ SQRRLSTSPD VIQGHQPRDN HTDHGGSAVL IVILTLALAA LIFRRIYLAN EYIFDFEL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards