About Exosome complex component CSL4
Exosome complex component CSL4 (EXOSC1) is a protein
from Homo sapiens identified by UniProt accession
Q9Y3B2, 195 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | Exosome complex component CSL4 |
|---|
| UniProt accession | Q9Y3B2 |
|---|
| Gene | EXOSC1 |
|---|
| Organism | Homo sapiens |
|---|
| Length | 195 residues |
|---|
| Molecular weight | — |
|---|
| EC numbers | — |
|---|
| Target class | UNCLASSIFIED |
|---|
| Subcellular location | — |
|---|
| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (94)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.52
- pontocerebellar hypoplasia, type 1F · score 0.45
- breast adenocarcinoma · score 0.10
- Familial short QT syndrome · score 0.07
- Romano-Ward syndrome · score 0.07
- Arrhythmogenic right ventricular dysplasia · score 0.07
- Brugada syndrome · score 0.07
- familial atrial fibrillation · score 0.06
- Familial progressive cardiac conduction defect · score 0.06
- hypertrophic cardiomyopathy · score 0.06
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y3B2-F1 | alphafold | PREDICTED | 78.42 | — |
Amino-acid sequence (195 residues)
MAPPVRYCIP GERLCNLEEG SPGSGTYTRH GYIFSSLAGC LMKSSENGAL PVVSVVRETE SQLLPDVGAI VTCKVSSINS RFAKVHILYV GSMPLKNSFR GTIRKEDVRA TEKDKVEIYK SFRPGDIVLA KVISLGDAQS NYLLTTAENE LGVVVAHSES GIQMVPISWC EMQCPKTHTK EFRKVARVQP EFLQT
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