Methionine-R-sulfoxide reductase B2, mitochondrial…

About Methionine-R-sulfoxide reductase B2, mitochondrial

Methionine-R-sulfoxide reductase B2, mitochondrial (MSRB2) is a protein from Homo sapiens identified by UniProt accession Q9Y3D2, 182 residues long. MolForge cross-references it against 0 known binders and 46 disease associations.

Target properties

Protein name	Methionine-R-sulfoxide reductase B2, mitochondrial
UniProt accession	Q9Y3D2
Gene	MSRB2
Organism	Homo sapiens
Length	182 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (46)

Diseases linked to this target (Open Targets).

metabolite measurement · score 0.08
diabetes mellitus · score 0.07
Parkinson disease · score 0.02
ovarian carcinoma · score 0.02
Sepsis · score 0.02
bacteriemia · score 0.02
Tularemia · score 0.01
Abnormal sperm morphology · score 0.01
ulcerative colitis · score 0.01
Alzheimer disease · score 0.01

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y3D2-F1	alphafold	PREDICTED	80.83	—

Amino-acid sequence (182 residues)

MARLLWLLRG LTLGTAPRRA VRGQAGGGGP GTGPGLGEAG SLATCELPLA KSEWQKKLTP EQFYVTREKG TEPPFSGIYL NNKEAGMYHC VCCDSPLFSS EKKYCSGTGW PSFSEAHGTS GSDESHTGIL RRLDTSLGSA RTEVVCKQCE AHLGHVFPDG PGPNGQRFCI NSVALKFKPR KH

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards

Methionine-R-sulfoxide reductase B2, mitochondrial (MSRB2)