Protein chibby homolog 1 (CBY1)

About Protein chibby homolog 1

Protein chibby homolog 1 (CBY1) is a protein from Homo sapiens identified by UniProt accession Q9Y3M2, 126 residues long. MolForge cross-references it against 0 known binders and 98 disease associations.

Target properties

Protein name	Protein chibby homolog 1
UniProt accession	Q9Y3M2
Gene	CBY1
Organism	Homo sapiens
Length	126 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (98)

Diseases linked to this target (Open Targets).

Joubert syndrome · score 0.55
Polydactyly · score 0.37
polydactyly · score 0.37
cerebellar ataxia · score 0.37
Intellectual disability · score 0.37
Molar tooth sign on MRI · score 0.37
mean corpuscular volume · score 0.19
endometrial cancer · score 0.18
hemoglobin measurement · score 0.17
mean corpuscular hemoglobin concentration · score 0.17

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y3M2-F1	alphafold	PREDICTED	85.75	—

Amino-acid sequence (126 residues)

MPFFGNTFSP KKTPPRKSAS LSNLHSLDRS TREVELGLEY GSPTMNLAGQ SLKFENGQWI AETGVSGGVD RREVQRLRRR NQQLEEENNL LRLKVDILLD MLSESTAESH LMEKELDELR ISRKRK

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards