Rhomboid domain-containing protein 3 (RHBDD3)

About Rhomboid domain-containing protein 3

Rhomboid domain-containing protein 3 (RHBDD3) is a protein from Homo sapiens identified by UniProt accession Q9Y3P4, 386 residues long. MolForge cross-references it against 0 known binders and 48 disease associations.

Target properties

Protein name	Rhomboid domain-containing protein 3
UniProt accession	Q9Y3P4
Gene	RHBDD3
Organism	Homo sapiens
Length	386 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (48)

Diseases linked to this target (Open Targets).

neurodegenerative disease · score 0.36
reticulocyte count · score 0.06
monocyte count · score 0.05
platelet count · score 0.05
reticulocyte measurement · score 0.05
neutrophil count · score 0.05
leukocyte count · score 0.05
X-linked lymphoproliferative disease · score 0.05
Familial hemophagocytic lymphohistiocytosis · score 0.04
lymphocyte count · score 0.04

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y3P4-F1	alphafold	PREDICTED	69.52	—

Amino-acid sequence (386 residues)

MHARGPHGQL SPALPLASSV LMLLMSTLWL VGAGPGLVLA PELLLDPWQV HRLLTHALGH TALPGLLLSL LLLPTVGWQQ ECHLGTLRFL HASALLALAS GLLAVLLAGL GLSSAAGSCG YMPVHLAMLA GEGHRPRRPR GALPPWLSPW LLLALTPLLS SEPPFLQLLC GLLAGLAYAA GAFRWLEPSE RRLQVLQEGV LCRTLAGCWP LRLLATPGSL AELPVTHPAG VRPPIPGPPY VASPDLWSHW EDSALPPPSL RPVQPTWEGS SEAGLDWAGA SFSPGTPMWA ALDEQMLQEG IQASLLDGPA QEPQSAPWLS KSSVSSLRLQ QLERMGFPTE QAVVALAATG RVEGAVSLLV GGQVGTETLV THGKGGPAHS EGPGPP

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards