About Rab GTPase-activating protein 1
Rab GTPase-activating protein 1 (RABGAP1) is a protein
from Homo sapiens identified by UniProt accession
Q9Y3P9, 1069 residues long.
MolForge cross-references it against 0 known binders and
59 disease associations.
Target properties
| Protein name | Rab GTPase-activating protein 1 |
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| UniProt accession | Q9Y3P9 |
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| Gene | RABGAP1 |
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| Organism | Homo sapiens |
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| Length | 1069 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (59)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.53
- lysosomal storage disease · score 0.25
- systolic blood pressure · score 0.24
- vitamin D measurement · score 0.23
- birth weight · score 0.22
- pulse pressure measurement · score 0.18
- aspartate aminotransferase measurement · score 0.17
- sex hormone-binding globulin measurement · score 0.16
- body height · score 0.14
- neuroimaging measurement · score 0.13
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y3P9-F1 | alphafold | PREDICTED | 76.42 | — |
Amino-acid sequence (1069 residues)
MDDKASVGKI SVSSDSVSTL NSEDFVLVSR QGDETPSTNN GSDDEKTGLK IVGNGSEQQL QKELADVLMD PPMDDQPGEK ELVKRSQLDG EGDGPLSNQL SASSTINPVP LVGLQKPEMS LPVKPGQGDS EASSPFTPVA DEDSVVFSKL TYLGCASVNA PRSEVEALRM MSILRSQCQI SLDVTLSVPN VSEGIVRLLD PQTNTEIANY PIYKILFCVR GHDGTPESDC FAFTESHYNA ELFRIHVFRC EIQEAVSRIL YSFATAFRRS AKQTPLSATA APQTPDSDIF TFSVSLEIKE DDGKGYFSAV PKDKDRQCFK LRQGIDKKIV IYVQQTTNKE LAIERCFGLL LSPGKDVRNS DMHLLDLESM GKSSDGKSYV ITGSWNPKSP HFQVVNEETP KDKVLFMTTA VDLVITEVQE PVRFLLETKV RVCSPNERLF WPFSKRSTTE NFFLKLKQIK QRERKNNTDT LYEVVCLESE SERERRKTTA SPSVRLPQSG SQSSVIPSPP EDDEEEDNDE PLLSGSGDVS KECAEKILET WGELLSKWHL NLNVRPKQLS SLVRNGVPEA LRGEVWQLLA GCHNNDHLVE KYRILITKES PQDSAITRDI NRTFPAHDYF KDTGGDGQDS LYKICKAYSV YDEEIGYCQG QSFLAAVLLL HMPEEQAFSV LVKIMFDYGL RELFKQNFED LHCKFYQLER LMQEYIPDLY NHFLDISLEA HMYASQWFLT LFTAKFPLYM VFHIIDLLLC EGISVIFNVA LGLLKTSKDD LLLTDFEGAL KFFRVQLPKR YRSEENAKKL MELACNMKIS QKKLKKYEKE YHTMREQQAQ QEDPIERFER ENRRLQEANM RLEQENDDLA HELVTSKIAL RKDLDNAEEK ADALNKELLM TKQKLIDAEE EKRRLEEESA QLKEMCRREL DKAESEIKKN SSIIGDYKQI CSQLSERLEK QQTANKVEIE KIRQKVDDCE RCREFFNKEG RVKGISSTKE VLDEDTDEEK ETLKNQLREM ELELAQTKLQ LVEAECKIQD LEHHLGLALN EVQAAKKTWF NRTLSSIKTA TGVQGKETC
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