T-box transcription factor TBX22 (TBX22)

About T-box transcription factor TBX22

T-box transcription factor TBX22 (TBX22) is a protein from Homo sapiens identified by UniProt accession Q9Y458, 520 residues long. MolForge cross-references it against 0 known binders and 88 disease associations.

Target properties

Protein name	T-box transcription factor TBX22
UniProt accession	Q9Y458
Gene	TBX22
Organism	Homo sapiens
Length	520 residues
Molecular weight	—
EC numbers	—
Target class	UNCLASSIFIED
Subcellular location	—
Keywords	—

Druggability

Target tractability assessment (Open Targets + pocket analysis). No approved drug

Druggability tier	MEDIUM
Druggability score	—
Pocket score	—
Max clinical phase	—

Disease associations (88)

Diseases linked to this target (Open Targets).

cleft palate with or without ankyloglossia, X-linked · score 0.75
Abruzzo-Erickson syndrome · score 0.50
neurodegenerative disease · score 0.42
Cleft palate · score 0.41
cleft palate · score 0.38
cleft lip · score 0.37
lysosomal storage disease · score 0.26
Alzheimer disease · score 0.26
Parkinson disease · score 0.26
multiple sclerosis · score 0.26

3D Structure (1)

Experimental (PDB) and predicted (AlphaFold) structures for this protein.

Structure	Source	Method	Mean pLDDT	Resolution (Å)
AF-Q9Y458-F1	alphafold	PREDICTED	58.42	—

Amino-acid sequence (520 residues)

MALSSRARAF SVEALVGRPS KRKLQDPIQA EQPELREKKG GEEEEERRSS AAGKSEPLEK QPKTEPSTSA SSGCGSDSGY GNSSESLEEK DIQMELQGSE LWKRFHDIGT EMIITKAGRR MFPSVRVKVK GLDPGKQYHV AIDVVPVDSK RYRYVYHSSQ WMVAGNTDHL CIIPRFYVHP DSPCSGETWM RQIISFDRMK LTNNEMDDKG HIILQSMHKY KPRVHVIEQG SSVDLSQIQS LPTEGVKTFS FKETEFTTVT AYQNQQITKL KIERNPFAKG FRDTGRNRGV LDGLLETYPW RPSFTLDFKT FGADTQSGSS GSSPVTSSGG APSPLNSLLS PLCFSPMFHL PTSSLGMPCP EAYLPNVNLP LCYKICPTNF WQQQPLVLPA PERLASSNSS QSLAPLMMEV PMLSSLGVTN SKSGSSEDSS DQYLQAPNST NQMLYGLQSP GNIFLPNSIT PEALSCSFHP SYDFYRYNFS MPSRLISGSN HLKVNDDSQV SFGEGKCNHV HWYPAINHYL

External references

UniProt AlphaFold QuickGO RCSB PDB GeneCards