About Dual specificity tyrosine-phosphorylation-regulated kinase 1B
Dual specificity tyrosine-phosphorylation-regulated kinase 1B (DYRK1B) is a protein
from Homo sapiens identified by UniProt accession
Q9Y463, 629 residues long.
MolForge cross-references it against 0 known binders and
94 disease associations.
Target properties
| Protein name | Dual specificity tyrosine-phosphorylation-regulated kinase 1B |
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| UniProt accession | Q9Y463 |
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| Gene | DYRK1B |
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| Organism | Homo sapiens |
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| Length | 629 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Approved drugs hitting this target (10)
DrugCentral-linked approved drugs that act on this protein.
Disease associations (94)
Diseases linked to this target (Open Targets).
- metabolic syndrome · score 0.65
- neurodegenerative disease · score 0.54
- lysosomal storage disease · score 0.45
- multiple sclerosis · score 0.33
- Alzheimer disease · score 0.33
- Parkinson disease · score 0.33
- ganglion cell inner plexiform layer thickness measurement · score 0.24
- macula measurement · score 0.23
- genetic disorder · score 0.19
- myoepithelial tumor · score 0.11
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y463-F1 | alphafold | PREDICTED | 73.00 | — |
Amino-acid sequence (629 residues)
MAVPPGHGPF SGFPGPQEHT QVLPDVRLLP RRLPLAFRDA TSAPLRKLSV DLIKTYKHIN EVYYAKKKRR AQQAPPQDSS NKKEKKVLNH GYDDDNHDYI VRSGERWLER YEIDSLIGKG SFGQVVKAYD HQTQELVAIK IIKNKKAFLN QAQIELRLLE LMNQHDTEMK YYIVHLKRHF MFRNHLCLVF ELLSYNLYDL LRNTHFRGVS LNLTRKLAQQ LCTALLFLAT PELSIIHCDL KPENILLCNP KRSAIKIVDF GSSCQLGQRI YQYIQSRFYR SPEVLLGTPY DLAIDMWSLG CILVEMHTGE PLFSGSNEVD QMNRIVEVLG IPPAAMLDQA PKARKYFERL PGGGWTLRRT KELRKDYQGP GTRRLQEVLG VQTGGPGGRR AGEPGHSPAD YLRFQDLVLR MLEYEPAARI SPLGALQHGF FRRTADEATN TGPAGSSAST SPAPLDTCPS SSTASSISSS GGSSGSSSDN RTYRYSNRYC GGPGPPITDC EMNSPQVPPS QPLRPWAGGD VPHKTHQAPA SASSLPGTGA QLPPQPRYLG RPPSPTSPPP PELMDVSLVG GPADCSPPHP APAPQHPAAS ALRTRMTGGR PPLPPPDDPA TLGPHLGLRG VPQSTAASS
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