About Zinc finger protein 175
Zinc finger protein 175 (ZNF175) is a protein
from Homo sapiens identified by UniProt accession
Q9Y473, 711 residues long.
MolForge cross-references it against 0 known binders and
26 disease associations.
Target properties
| Protein name | Zinc finger protein 175 |
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| UniProt accession | Q9Y473 |
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| Gene | ZNF175 |
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| Organism | Homo sapiens |
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| Length | 711 residues |
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| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
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| Druggability score | — |
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| Pocket score | — |
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| Max clinical phase | — |
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Disease associations (26)
Diseases linked to this target (Open Targets).
- pancreatic adenocarcinoma · score 0.14
- hypertriglyceridemia 2 · score 0.07
- cholesterol-ester transfer protein deficiency · score 0.06
- thyroid hormone metabolism, abnormal, 2 · score 0.05
- sitosterolemia · score 0.05
- Combined hyperlipidemia · score 0.05
- homozygous familial hypercholesterolemia · score 0.05
- hypercholesterolemia, autosomal dominant, 3 · score 0.04
- hyperlipidemia due to hepatic triglyceride lipase deficiency · score 0.04
- hypercholesterolemia, autosomal dominant, type B · score 0.04
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y473-F1 | alphafold | PREDICTED | 61.41 | — |
Amino-acid sequence (711 residues)
MPADVNLSQK PQVLGPEKQD GSCEASVSFE DVTVDFSREE WQQLDPAQRC LYRDVMLELY SHLFAVGYHI PNPEVIFRML KEKEPRVEEA EVSHQRCQER EFGLEIPQKE ISKKASFQKD MVGEFTRDGS WCSILEELRL DADRTKKDEQ NQIQPMSHSA FFNKKTLNTE SNCEYKDPGK MIRTRPHLAS SQKQPQKCCL FTESLKLNLE VNGQNESNDT EQLDDVVGSG QLFSHSSSDA CSKNIHTGET FCKGNQCRKV CGHKQSLKQH QIHTQKKPDG CSECGGSFTQ KSHLFAQQRI HSVGNLHECG KCGKAFMPQL KLSVYLTDHT GDIPCICKEC GKVFIQRSEL LTHQKTHTRK KPYKCHDCGK AFFQMLSLFR HQRTHSREKL YECSECGKGF SQNSTLIIHQ KIHTGERQYA CSECGKAFTQ KSTLSLHQRI HSGQKSYVCI ECGQAFIQKA HLIVHQRSHT GEKPYQCHNC GKSFISKSQL DIHHRIHTGE KPYECSDCGK TFTQKSHLNI HQKIHTGERH HVCSECGKAF NQKSILSMHQ RIHTGEKPYK CSECGKAFTS KSQFKEHQRI HTGEKPYVCT ECGKAFNGRS NFHKHQITHT RERPFVCYKC GKAFVQKSEL ITHQRTHMGE KPYECLDCGK SFSKKPQLKV HQRIHTGERP YVCSECGKAF NNRSNFNKHQ TTHTRDKSYK CSYSVKGFTK Q
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