About Metal-response element-binding transcription factor 2
Metal-response element-binding transcription factor 2 (MTF2) is a protein
from Homo sapiens identified by UniProt accession
Q9Y483, 593 residues long.
MolForge cross-references it against 0 known binders and
175 disease associations.
Target properties
| Protein name | Metal-response element-binding transcription factor 2 |
|---|
| UniProt accession | Q9Y483 |
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| Gene | MTF2 |
|---|
| Organism | Homo sapiens |
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| Length | 593 residues |
|---|
| Molecular weight | — |
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| EC numbers | — |
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| Target class | UNCLASSIFIED |
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| Subcellular location | — |
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| Keywords | — |
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Druggability
Target tractability assessment (Open Targets + pocket analysis). No approved drug
| Druggability tier | MEDIUM |
|---|
| Druggability score | — |
|---|
| Pocket score | — |
|---|
| Max clinical phase | — |
|---|
Disease associations (175)
Diseases linked to this target (Open Targets).
- neurodegenerative disease · score 0.44
- monocyte count · score 0.27
- eosinophil count · score 0.20
- IGF-1 measurement · score 0.17
- lymphocyte:monocyte ratio · score 0.13
- endometrial cancer · score 0.11
- platelet count · score 0.10
- high density lipoprotein cholesterol measurement · score 0.10
- mean corpuscular volume · score 0.09
- eosinophil percentage of leukocytes · score 0.08
3D Structure (1)
Experimental (PDB) and predicted (AlphaFold) structures for this protein.
| Structure | Source | Method | Mean pLDDT | Resolution (Å) |
|---|
| AF-Q9Y483-F1 | alphafold | PREDICTED | 70.65 | — |
Amino-acid sequence (593 residues)
MRDSTGAGNS LVHKRSPLRR NQKTPTSLTK LSLQDGHKAK KPACKFEEGQ DVLARWSDGL FYLGTIKKIN ILKQSCFIIF EDSSKSWVLW KDIQTGATGS GEMVCTICQE EYSEAPNEMV ICDKCGQGYH QLCHTPHIDS SVIDSDEKWL CRQCVFATTT KRGGALKKGP NAKALQVMKQ TLPYSVADLE WDAGHKTNVQ QCYCYCGGPG DWYLKMLQCC KCKQWFHEAC VQCLQKPMLF GDRFYTFICS VCSSGPEYLK RLPLQWVDIA HLCLYNLSVI HKKKYFDSEL ELMTYINENW DRLHPGELAD TPKSERYEHV LEALNDYKTM FMSGKEIKKK KHLFGLRIRV PPVPPNVAFK AEKEPEGTSH EFKIKGRKAS KPISDSREVS NGIEKKGKKK SVGRPPGPYT RKMIQKTAEP LLDKESISEN PTLDLPCSIG RTEGTAHSSN TSDVDFTGAS SAKETTSSSI SRHYGLSDSR KRTRTGRSWP AAIPHLRRRR GRLPRRALQT QNSEIVKDDE GKEDYQFDEL NTEILNNLAD QELQLNHLKN SITSYFGAAG RIACGEKYRV LARRVTLDGK VQYLVEWEGA TAS
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